The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2023613118
Abstract: Significance Meiotic recombination promotes genetic diversity by shuffling parental chromosomes. As observed by the very first geneticists, crossovers inhibit the formation of another crossover nearby, an elusive phenomenon called crossover interference. Another intriguing observation is… read more here.
Keywords: heterochiasmy; interference; synaptonemal complex; formation ... See more keywords
The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab566
Abstract: Abstract The synaptonemal complex (SC) is a proteinaceous structure that mediates homolog engagement and genetic recombination during meiosis. In budding yeast, Zip-Mer-Msh (ZMM) proteins promote crossover (CO) formation and initiate SC formation. During SC elongation,… read more here.
Keywords: synaptonemal complex; central region; formation; recombination ... See more keywords
Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202301906
Abstract: Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids. During meiosis, programmed… read more here.
Keywords: dna; meiotic dna; dna exchanges; synaptonemal complex ... See more keywords
Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1005145
Abstract: During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination. Chromosomes that do not recombine or… read more here.
Keywords: synaptonemal analyzer; crossover; tool synaptonemal; analyzer tool ... See more keywords
Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1098468
Abstract: The synaptonemal complex (SC) is a dynamic structure formed between chromosomes during meiosis which stabilizes and supports many essential meiotic processes such as pairing and recombination. In budding yeast, Zip1 is a functionally conserved element… read more here.
Keywords: synaptonemal complex; final disassembly; abortive disassembly; assembly disassembly ... See more keywords
Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.998775
Abstract: Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility. However, a gynogenetic… read more here.
Keywords: meiosis; gynogenetic allodiploid; synaptonemal complex; allodiploid hybrid ... See more keywords
Alterations in synaptonemal complex coding genes and human infertility
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.67843
Abstract: About 10% of reproductive-aged couples suffer from infertility. However, the genetic causes of human infertility cases are largely unknown. Meiosis produces haploid gametes for fertilization and errors in meiosis are associated with human infertility in… read more here.
Keywords: alterations synaptonemal; human infertility; synaptonemal complex; infertility ... See more keywords
Polo-like kinase-dependent phosphorylation of the synaptonemal complex protein SYP-4 regulates double-strand break formation through a negative feedback loop.
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DOI: 10.7554/elife.23437
Abstract: The synaptonemal complex (SC) is an ultrastructurally conserved proteinaceous structure that holds homologous chromosomes together and is required for the stabilization of pairing interactions and the completion of crossover (CO) formation between homologs during meiosis… read more here.
Keywords: synaptonemal complex; syp; formation; polo like ... See more keywords
Author response: Unconventional conservation reveals structure-function relationships in the synaptonemal complex
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.72061.sa2
Abstract: Functional requirements constrain protein evolution, commonly manifesting in conserved primary amino acid sequence. Here, we extend this idea to secondary structural features by tracking their conservation in essential meiotic proteins with highly diverged sequences. The… read more here.
Keywords: structure function; synaptonemal complex; conservation; structure ... See more keywords