The synaptonemal complex central element SCEP3 interlinks synapsis initiation and crossover formation in Arabidopsis thaliana
Sign Up to like & getrecommendations! Published in 2025 at "Nature Plants"
DOI: 10.1038/s41477-025-02030-9
Abstract: The synaptonemal complex (SC) forms between homologous chromosomes during meiosis. In Arabidopsis thaliana, its central region (CR) is composed of the transverse filament protein ZYP1 and the central element proteins SCEP1 and SCEP2. Here we… read more here.
Keywords: crossover; scep3; synaptonemal complex; central element ... See more keywords
The synaptonemal complex imposes crossover interference and heterochiasmy in Arabidopsis
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2023613118
Abstract: Significance Meiotic recombination promotes genetic diversity by shuffling parental chromosomes. As observed by the very first geneticists, crossovers inhibit the formation of another crossover nearby, an elusive phenomenon called crossover interference. Another intriguing observation is… read more here.
Keywords: heterochiasmy; interference; synaptonemal complex; formation ... See more keywords
The structural role of Skp1 in the synaptonemal complex is conserved in nematodes
Sign Up to like & getrecommendations! Published in 2024 at "Genetics"
DOI: 10.1093/genetics/iyae153
Abstract: Abstract The synaptonemal complex (SC) is a meiotic interface that assembles between parental chromosomes and is essential for gamete formation. While the dimensions and ultrastructure of the SC are conserved across eukaryotes, its protein components… read more here.
Keywords: structural role; role; skr; synaptonemal complex ... See more keywords
Suppression of meiotic crossovers in pericentromeric heterochromatin requires synaptonemal complex and meiotic recombination factors in Drosophila melanogaster.
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DOI: 10.1093/genetics/iyaf029
Abstract: The centromere effect (CE) is a meiotic phenomenon that ensures meiotic crossover suppression in pericentromeric regions. Despite being a critical safeguard against nondisjunction, the mechanisms behind the CE remain unknown. Previous studies found that different… read more here.
Keywords: crossover; heterochromatin; recombination factors; meiotic recombination ... See more keywords
The synaptonemal complex central region modulates crossover pathways and feedback control of meiotic double-strand break formation
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab566
Abstract: Abstract The synaptonemal complex (SC) is a proteinaceous structure that mediates homolog engagement and genetic recombination during meiosis. In budding yeast, Zip-Mer-Msh (ZMM) proteins promote crossover (CO) formation and initiate SC formation. During SC elongation,… read more here.
Keywords: synaptonemal complex; central region; formation; recombination ... See more keywords
Meiotic Arrest and Synaptonemal Complex Failure in Infertile Men with Y Chromosome Microdeletions
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DOI: 10.1159/000547448
Abstract: Abstract Background: The Y chromosome microdeletions are common genetic cause of male infertility. Mechanisms of impaired spermatogenesis and meiosis, as well as phenotypic variability, have not been sufficiently studied. Objective: The paper provides results of… read more here.
Keywords: infertile men; meiotic arrest; chromosome microdeletions; synaptonemal complex ... See more keywords
Meiotic DNA exchanges in C. elegans are promoted by proximity to the synaptonemal complex
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DOI: 10.26508/lsa.202301906
Abstract: Exchanges between DNA molecules during meiosis are tightly controlled. This work shows that the synaptonemal complex is instrumental in regulating meiotic exchanges both between the parental chromosomes and between the sister chromatids. During meiosis, programmed… read more here.
Keywords: dna; meiotic dna; dna exchanges; synaptonemal complex ... See more keywords
Synaptonemal & CO analyzer: A tool for synaptonemal complex and crossover analysis in immunofluorescence images
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1005145
Abstract: During the formation of ova and sperm, homologous chromosomes get physically attached through the synaptonemal complex and exchange DNA at crossover sites by a process known as meiotic recombination. Chromosomes that do not recombine or… read more here.
Keywords: synaptonemal analyzer; crossover; tool synaptonemal; analyzer tool ... See more keywords
Kinetic analysis of synaptonemal complex dynamics during meiosis of yeast Saccharomyces cerevisiae reveals biphasic growth and abortive disassembly
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DOI: 10.3389/fcell.2023.1098468
Abstract: The synaptonemal complex (SC) is a dynamic structure formed between chromosomes during meiosis which stabilizes and supports many essential meiotic processes such as pairing and recombination. In budding yeast, Zip1 is a functionally conserved element… read more here.
Keywords: synaptonemal complex; final disassembly; abortive disassembly; assembly disassembly ... See more keywords
Formation of the synaptonemal complex in a gynogenetic allodiploid hybrid fish
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DOI: 10.3389/fgene.2023.998775
Abstract: Introduction: The correct pairing and separation of homologous chromosomes during meiosis is crucial to ensure both genetic stability and genetic diversity within species. In allodiploid organisms, synapsis often fails, leading to sterility. However, a gynogenetic… read more here.
Keywords: meiosis; gynogenetic allodiploid; synaptonemal complex; allodiploid hybrid ... See more keywords
Alterations in synaptonemal complex coding genes and human infertility
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.67843
Abstract: About 10% of reproductive-aged couples suffer from infertility. However, the genetic causes of human infertility cases are largely unknown. Meiosis produces haploid gametes for fertilization and errors in meiosis are associated with human infertility in… read more here.
Keywords: alterations synaptonemal; human infertility; synaptonemal complex; infertility ... See more keywords