CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects
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DOI: 10.1016/j.ibror.2020.04.001
Abstract: Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic… read more here.
Keywords: protein; associated protein; synaptosomal associated; first episode ... See more keywords
Interaction of Synaptosomal-Associated Protein 25 with Neutral Sphingomyelinase 2: Functional Impact on the Sphingomyelin Pathway
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DOI: 10.1016/j.neuroscience.2019.08.015
Abstract: Neurotransmitter release is mediated by ceramide, which is generated by sphingomyelin hydrolysis. In the present study, we examined whether synaptosomal-associated protein 25 (SNAP-25) is involved in ceramide production and exocytosis. Neutral sphingomyelinase 2 (nSMase2) was… read more here.
Keywords: associated protein; synaptosomal associated; neutral sphingomyelinase; release ... See more keywords
OnabotulinumtoxinA effects on trigeminal nociceptors
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DOI: 10.1177/03331024221141683
Abstract: Background OnabotulinumtoxinA (onabotA) is approved globally for prevention of chronic migraine; however, the classical mechanism of action of onabotA in motor and autonomic neurons cannot fully explain the effectiveness of onabotulinumtoxinA in this sensory neurological… read more here.
Keywords: protein; inflammatory soup; associated protein; synaptosomal associated ... See more keywords