The Synaptotagmin-1 C2B Domain Is a Key Regulator in the Stabilization of the Fusion Pore.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.0c00734
Abstract: Fusion pores serve as an effective mechanism to connect intracellular organelles and release vesicle contents during exocytosis. A complex lipid rearrangement takes place as membranes approximate, bend, fuse, and establish a traversing water channel to… read more here.
Keywords: fusion; fusion pore; synaptotagmin c2b; c2b domain ... See more keywords
Enhanced Expansion and Reduced Kiss-and-Run Events in Fusion Pores Steered by Synaptotagmin-1 C2B Domains.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00424
Abstract: The fusion pore controls the release of exocytotic vesicle contents through a precise orchestration of lipids from the fusing membranes and proteins. There is a major lipid reorganization during the different stages in life of… read more here.
Keywords: fusion; synaptotagmin c2b; fusion pore; c2b domains ... See more keywords