Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2018.09.018
Abstract: Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine… read more here.
Keywords: hsv; tegument protein; protein ul16; cell ... See more keywords
Anti-Fungal Drug Anidulafungin Inhibits SARS-CoV-2 Spike-Induced Syncytia Formation by Targeting ACE2-Spike Protein Interaction
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DOI: 10.3389/fgene.2022.866474
Abstract: Drug repositioning continues to be the most effective, practicable possibility to treat COVID-19 patients. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus enters target cells by binding to the ACE2 receptor via its spike… read more here.
Keywords: syncytia formation; spike; ace2 spike; drug ... See more keywords
Fusion assays for screening of fusion inhibitors targeting SARS-CoV-2 entry and syncytia formation
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DOI: 10.3389/fphar.2022.1007527
Abstract: Virus fusion process is evolutionarily conserved and provides a promising pan-viral target. Cell-cell fusion leads to syncytial formation and has implications in pathogenesis, virus spread and immune evasion. Drugs that target these processes can be… read more here.
Keywords: fusion; syncytia formation; fusion inhibitors; fusion assays ... See more keywords
Methamphetamine Induces the Release of Proadhesive Extracellular Vesicles and Promotes Syncytia Formation: A Potential Role in HIV-1 Neuropathogenesis
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DOI: 10.3390/v14030550
Abstract: Despite the success of combinational antiretroviral therapy (cART), the high pervasiveness of human immunodeficiency virus-1 (HIV)-associated neurocognitive disorders (HAND) poses a significant challenge for society. Methamphetamine (meth) and related amphetamine compounds, which are potent psychostimulants,… read more here.
Keywords: hiv; extracellular vesicles; syncytia formation; release proadhesive ... See more keywords