Endocannabinoid signaling impairs syncytialization: Using flow cytometry to evaluate forskolin-induced cell fusion.
Sign Up to like & getrecommendations! Published in 2020 at "Placenta"
DOI: 10.1016/j.placenta.2020.10.028
Abstract: Cytotrophoblast cells fuse to form the syncytiotrophoblast, the main structure responsible for the placenta's specialized functions. This complex process denominated syncytialization is fundamental for a correct pregnancy outcome. We observed that the endocannabinoid anandamide disrupts… read more here.
Keywords: cell; signaling impairs; endocannabinoid signaling; flow cytometry ... See more keywords
Effects of selective serotonin‐reuptake inhibitors (SSRIs) on human villous trophoblasts syncytialization
Sign Up to like & getrecommendations! Published in 2018 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2018.04.018
Abstract: ABSTRACT Selective serotonin‐reuptake inhibitors (SSRIs) are the most commonly prescribed antidepressants during pregnancy. The human placenta is a highly specialized organ supporting normal growth and development of the fetus. Therefore, this study aims to analyze… read more here.
Keywords: selective serotonin; villous trophoblasts; trophoblast; syncytialization ... See more keywords
Trichloroethylene Metabolite S-(1,2-Dichlorovinyl)-l-cysteine Stimulates Changes in Energy Metabolites and Amino Acids in the BeWo Human Placental Trophoblast Model during Syncytialization.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.3c00007
Abstract: Syncytialization, the fusion of cytotrophoblasts into an epithelial barrier that constitutes the maternal-fetal interface, is a crucial event of placentation. This process is characterized by distinct changes to amino acid and energy metabolism. A metabolite… read more here.
Keywords: amino acids; energy metabolism; energy; changes energy ... See more keywords
Integrin linked kinase regulates syncytialization of BeWo trophoblast cells†
Sign Up to like & getrecommendations! Published in 2017 at "Biology of Reproduction"
DOI: 10.1095/biolreprod.116.145748
Abstract: Abstract During placental development, mononuclear villous cytotrophoblast cells differentiate and fuse with the overlying syncytiotrophoblast. This process requires the dissolution of E-cadherin (CDH1)-containing adherens junctions in cytotrophoblast. Integrin linked kinase (ILK) can downregulate CDH1 through… read more here.
Keywords: parp1 snai1; syncytialization; bewo; ilk ... See more keywords
Bisphenol S and Epidermal Growth Factor Receptor Signaling in Human Placental Cytotrophoblasts
Sign Up to like & getrecommendations! Published in 2021 at "Environmental Health Perspectives"
DOI: 10.1289/ehp7297
Abstract: Background: Bisphenol S (BPS) is an endocrine-disrupting chemical and the second most abundant bisphenol detected in humans. In vivo BPS exposure leads to reduced binucleate cell number in the ovine placenta. Binucleate cells form by… read more here.
Keywords: bps; growth; syncytialization; cell ... See more keywords
Syncytialization and prolonged exposure to palmitate impacts BeWo respiration.
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction"
DOI: 10.1530/rep-19-0433
Abstract: Placental villous trophoblast mitochondrial respiratory function is critical for a successful pregnancy and environmental influences such as maternal obesity have been associated with respiratory impairment at term. More recently, a gestational high fat diet independent… read more here.
Keywords: respiratory; activity; syncytialization; cell ... See more keywords
LMNA Determines Nuclear Morphology During Syncytialization of Human Trophoblast Stem Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.836390
Abstract: Upon implantation, the trophectoderm differentiates into the multi-nucleated primitive syncytiotrophoblast (pSTB) through a process called primary syncytialization to facilitate maternal-fetal interactions and to establish a pregnancy. However, ethical issues and limited access to human embryos… read more here.
Keywords: stem cells; human trophoblast; trophoblast stem; syncytialization ... See more keywords
S100P promotes trophoblast syncytialization during early placenta development by regulating YAP1
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.860261
Abstract: Recurrent pregnancy loss (RPL) is a severe complication of pregnancy that is caused by genetic abnormalities, immune dysfunction, aberrant cell biology, and tissue structure destruction. Among which, placental dysfunction is crucial in the pathogenetic progression… read more here.
Keywords: rpl; development; syncytialization; pregnancy ... See more keywords
Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1107182
Abstract: Placental dysfunction refers to the insufficiency of placental perfusion and chronic hypoxia during early pregnancy, which impairs placental function and causes inadequate supply of oxygen and nutrients to the fetus, affecting fetal development and health.… read more here.
Keywords: trophoblast syncytialization; growth restriction; intrauterine growth; syncytialization ... See more keywords
Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23041955
Abstract: The serine protease inhibitor alpha1-antitrypsin (A1AT) may possess protective functions of impaired organs in a manner independent of its protease inhibitor activity. A1AT expression has been shown to fluctuate in patients with pregnancy-induced hypertension, which… read more here.
Keywords: expression; inflammatory; a1at may; syncytialization ... See more keywords