Potentially reduced fusogenicity of syncytin‐2 in New World monkeys
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DOI: 10.1002/2211-5463.13555
Abstract: Syncytin‐2 is a membrane fusion protein involved in placenta development that is derived from the endogenous retrovirus envelope gene acquired in the common ancestral lineage of New World and Old World monkeys (OWMs). It is… read more here.
Keywords: fusion; world; world monkeys; syncytin ... See more keywords
Expression of the syncytin-1 and syncytin-2 genes in the trophoblastic tissue of the early pregnancy losses with normal and abnormal karyotypes.
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DOI: 10.1016/j.gene.2020.144533
Abstract: BACKGROUND Syncytin-1 and syncytin-2 which are endogenous retroviral genes products play a great role in syncytialization during trophoblast differentiation in normal placental tissues. In aneuploidic placentas due to the low level of pregnancy-induced hormones an… read more here.
Keywords: syncytin syncytin; syncytin genes; expression; syncytin ... See more keywords
Up-regulation of syncytin-1 contributes to TNF-α-enhanced fusion between OSCC and HUVECs partly via Wnt/β-catenin-dependent pathway
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DOI: 10.1038/srep40983
Abstract: Accumulating evidence implies that cell fusion is one of the driving forces of cancer invasion and metastasis. However, considerably less is still known about the triggering factors and underlying mechanisms associated with cancer-host cell fusion,… read more here.
Keywords: pathway; syncytin; regulation syncytin; fusion ... See more keywords
Serum circulating free DNA of syncytin-1 as a novel molecular marker for early diagnosis of non-small-cell lung cancer.
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers in medicine"
DOI: 10.2217/bmm-2022-0499
Abstract: Background: Liquid biopsy has been receiving attention as an emerging detection technology in the clinical application of non-small-cell lung cancer (NSCLC). Methods: We quantified serum circulating free DNA (cfDNA) of syncytin-1 in 126 patients and… read more here.
Keywords: lung cancer; cfdna syncytin; non small; syncytin ... See more keywords
The Role of Syncytin in Placental Angiogenesis and Fetal Growth
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DOI: 10.3389/fcell.2022.852561
Abstract: Background: Syncytin, a retroviral envelope protein, is specifically expressed on trophoblast cells and mediates formation of the syncytiotrophoblast through fusogenic activity. Decreased expression of Syncytin was found in fetal growth restriction placentas. Results: By generating… read more here.
Keywords: growth; syncytin; role syncytin; fetal growth ... See more keywords
Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10030238
Abstract: Simple Summary The anti-vaccination movement claims an alleged danger of the COVID-19 vaccine based on the presupposed similarity between syncytin, which plays a role in human placentation and the SARS-CoV-2 spike protein. We argue that… read more here.
Keywords: protein; cov spike; spike protein; covid ... See more keywords