Presentation and diagnosis of autoimmune lymphoproliferative syndrome (ALPS)
Sign Up to like & getrecommendations! Published in 2021 at "Expert Review of Clinical Immunology"
DOI: 10.1080/1744666x.2021.1978842
Abstract: ABSTRACT Introduction Autoimmune lymphoproliferative syndrome (ALPS) is a rare disorder of immune dysregulation characterized by derangements in first apoptosis signal-mediated apoptosis and elevations in CD3+TCRαβ+CD4−CD8− ‘double negative’ T cells. As our understanding of this pleomorphic… read more here.
Keywords: diagnosis; lymphoproliferative syndrome; presentation diagnosis; syndrome alps ... See more keywords
Use of Sirolimus (Rapamycin) for Treatment of Cytopenias and Lymphoproliferation Linked to Autoimmune Lymphoproliferative Syndrome (ALPS). Two Case Reports
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000000785
Abstract: Autoimmune lymphoproliferative syndrome (ALPS) is a disorder of lymphocyte apoptosis. Children present with chronic nonmalignant lymphadenopathy, hepatosplenomegaly, and autoimmune cytopenias. Recent advances show efficacy of treatment with immunosuppressive drugs. Sirolimus, an mammalian target of rapamycin… read more here.
Keywords: lymphoproliferation; syndrome alps; treatment; lymphoproliferative syndrome ... See more keywords