CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation
Sign Up to like & getrecommendations! Published in 2018 at "Hippocampus"
DOI: 10.1002/hipo.22832
Abstract: Although there are changes in gene expression and alterations in neuronal density and afferent inputs in the forebrain of trisomic mouse models of Down syndrome (DS) and Alzheimer's disease (AD), there is a lack of… read more here.
Keywords: alzheimer disease; ca1 pyramidal; gene expression; syndrome alzheimer ... See more keywords
Synaptic actin stabilization protein loss in Down syndrome and Alzheimer disease
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DOI: 10.1111/bpa.12779
Abstract: Reduced spine densities and age‐dependent accumulation of amyloid β and tau pathology are shared features of Down syndrome (DS) and Alzheimer's disease (AD). Both spine morphology and the synaptic plasticity that supports learning depend upon… read more here.
Keywords: actin stabilization; alzheimer disease; syndrome alzheimer; pathology ... See more keywords
GIRK2 Channels in Down syndrome and Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2022 at "Current Alzheimer research"
DOI: 10.2174/1567205020666221223122110
Abstract: Cognitive impairment in Down syndrome (DS) results from the abnormal expression of hundreds of genes. However, the impact of KCNJ6, a gene located in the middle of the 'Down syndrome critical region' of chromosome 21,… read more here.
Keywords: alzheimer disease; girk2 channels; channels syndrome; syndrome alzheimer ... See more keywords