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Published in 2018 at "Hippocampus"
DOI: 10.1002/hipo.22832
Abstract: Although there are changes in gene expression and alterations in neuronal density and afferent inputs in the forebrain of trisomic mouse models of Down syndrome (DS) and Alzheimer's disease (AD), there is a lack of…
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Keywords:
alzheimer disease;
ca1 pyramidal;
gene expression;
syndrome alzheimer ... See more keywords
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Published in 2019 at "Brain Pathology"
DOI: 10.1111/bpa.12779
Abstract: Reduced spine densities and age‐dependent accumulation of amyloid β and tau pathology are shared features of Down syndrome (DS) and Alzheimer's disease (AD). Both spine morphology and the synaptic plasticity that supports learning depend upon…
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Keywords:
actin stabilization;
alzheimer disease;
syndrome alzheimer;
pathology ... See more keywords
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Published in 2022 at "Current Alzheimer research"
DOI: 10.2174/1567205020666221223122110
Abstract: Cognitive impairment in Down syndrome (DS) results from the abnormal expression of hundreds of genes. However, the impact of KCNJ6, a gene located in the middle of the 'Down syndrome critical region' of chromosome 21,…
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Keywords:
alzheimer disease;
girk2 channels;
channels syndrome;
syndrome alzheimer ... See more keywords