Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders
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DOI: 10.1007/s11892-020-01327-7
Abstract: The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown… read more here.
Keywords: syndromic obesity; bariatric surgery; obesity disorders; genetic obesity ... See more keywords
Reviewed and updated Algorithm for Genetic Characterization of Syndromic Obesity Phenotypes
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DOI: 10.2174/1389202923666220426093436
Abstract: Background: Individuals with a phenotype of early-onset severe obesity associated with intellectual disability can have molecular diagnoses ranging from monogenic to complex genetic traits. Severe overweight is the major sign of a syndromic physical appearance… read more here.
Keywords: intellectual disability; reviewed updated; syndromic obesity; obesity ... See more keywords
Biallelic mutations in P4HTM cause syndromic obesity.
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DOI: 10.2337/db22-1017
Abstract: We previously demonstrated that 50% of children with obesity from consanguineous families from Pakistan carried pathogenic variants in known monogenic obesity genes. Here, we have discovered a novel monogenetic recessive form of severe childhood obesity,… read more here.
Keywords: cause syndromic; mutations p4htm; p4htm cause; biallelic mutations ... See more keywords
Genetics of Obesity in Humans: A Clinical Review
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DOI: 10.3390/ijms231911005
Abstract: Obesity is a complex multifactorial disorder with genetic and environmental factors. There is an increase in the worldwide prevalence of obesity in both developed and developing countries. The development of genome-wide association studies (GWAS) and… read more here.
Keywords: genetics obesity; humans clinical; syndromic obesity; obesity ... See more keywords