Promising synergistic activity of fluconazole with bioactive Guttiferone-A and derivatives against non-albicans Candida species.
Sign Up to like & getrecommendations! Published in 2018 at "Journal de mycologie medicale"
DOI: 10.1016/j.mycmed.2018.07.006
Abstract: Natural products with diverse bioactivities and structures are an important source of novel chemicals with pharmaceutical potentials. Combinations of bioactive compounds with classical antimicrobial agents against drug-resistant or low-susceptible Candida spp. have been studied. Guttiferone-A… read more here.
Keywords: activity fluconazole; synergistic activity; candida spp; guttiferone ... See more keywords
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01257
Abstract: Metallo-β-lactamases (MBLs) contribute to the resistance of Gram-negative bacteria to carbapenems, last-resort antibiotics at hospital, and MBL inhibitors are urgently needed to preserve these important antibacterial drugs. Here, we describe a series of 1,2,4-triazole-3-thione-based inhibitors… read more here.
Keywords: clinical isolates; potent synergistic; synergistic activity; metallo ... See more keywords
High-efficiency RNA-based reprogramming of human primary fibroblasts
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03190-3
Abstract: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine; however, their potential clinical application is hampered by the low efficiency of somatic cell reprogramming. Here, we show that the synergistic activity of synthetic… read more here.
Keywords: medicine; primary fibroblasts; synergistic activity; reprogramming human ... See more keywords
Synergistic activity of Hsp90 inhibitors and anticancer agents in pancreatic cancer cell cultures
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52652-1
Abstract: Heat shock protein 90 (Hsp90) is a widely investigated target for anticancer therapy. The experimental Hsp90 inhibitors ICPD47 and ICPD62 demonstrated anticancer activity against colorectal, osteosarcoma and cervical cancer cell lines. However, their anticancer activity… read more here.
Keywords: synergistic activity; pancreatic cancer; cancer cell; cell ... See more keywords
Synergistic activity of antibodies in the multicomponent 4CMenB vaccine
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Vaccines"
DOI: 10.1080/14760584.2022.2050697
Abstract: ABSTRACT Introduction Vaccines based on multiple antigens often induce an immune response, which is higher than that triggered by each single component, with antibodies acting cooperatively and synergistically in tackling the infection. Areas covered An… read more here.
Keywords: multicomponent 4cmenb; synergistic activity; activity antibodies; activity ... See more keywords
Synergistic activity between Triphala and selected antibiotics against drug resistant clinical isolates
Sign Up to like & getrecommendations! Published in 2019 at "BMC Complementary and Alternative Medicine"
DOI: 10.1186/s12906-019-2618-1
Abstract: BackgroundTriphala is an indigenous medical product used for a variety of diseases. This study was conducted to determine the effect of Triphala on antibiotic properties of gentamicin and oxacillin against multi-drug resistant organisms.MethodsThe checkerboard method… read more here.
Keywords: triphala; drug resistant; gram negative; synergistic activity ... See more keywords
The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.963901
Abstract: Yersinia pseudotuberculosis is a foodborne zoonotic bacterium that is pathogenic to guinea pigs, rabbits, and mice. It also causes pseudotuberculosis in humans. However, it still lacked the scientific basis for control. Here, we found out… read more here.
Keywords: assessment synergistic; synergistic activity; yersinia pseudotuberculosis; activity ... See more keywords
The synergistic activity of SBC3 in combination with Ebselen against Escherichia coli infection
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.1080281
Abstract: Escherichia coli ranks as the number one clinical isolate in the past years in China according to The China Antimicrobial Surveillance Network (CHINET), and its multidrug-resistant (MDR) pathogenic strains account for over 160 million cases… read more here.
Keywords: combination ebselen; escherichia coli; synergistic activity; combination ... See more keywords
Synergistic Activity of Thymol with Commercial Antibiotics against Critical and High WHO Priority Pathogenic Bacteria
Sign Up to like & getrecommendations! Published in 2023 at "Plants"
DOI: 10.3390/plants12091868
Abstract: The use of synergistic combinations between natural compounds and commercial antibiotics may be a good strategy to fight against microbial resistance, with fewer side effects on human, animal and environmental, health. The antimicrobial capacity of… read more here.
Keywords: commercial antibiotics; pathogenic bacteria; priority; synergistic activity ... See more keywords