In silico-based screen synergistic drug combinations from herb medicines: a case using Cistanche tubulosa
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16571-3
Abstract: Neuroinflammation is characterized by the elaborated inflammatory response repertoire of central nervous system tissue. The limitations of the current treatments for neuroinflammation are well-known side effects in the clinical trials of monotherapy. Drug combination therapies… read more here.
Keywords: herb medicines; drug; cistanche tubulosa; combinations herb ... See more keywords
PRODeepSyn: predicting anticancer synergistic drug combinations by embedding cell lines with protein–protein interaction network
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbab587
Abstract: Abstract Although drug combinations in cancer treatment appear to be a promising therapeutic strategy with respect to monotherapy, it is arduous to discover new synergistic drug combinations due to the combinatorial explosion. Deep learning technology… read more here.
Keywords: network; drug combinations; synergistic drug; cell lines ... See more keywords
SNRMPACDC: computational model focused on Siamese network and random matrix projection for anticancer synergistic drug combination prediction
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac503
Abstract: Synergistic drug combinations can improve the therapeutic effect and reduce the drug dosage to avoid toxicity. In previous years, an in vitro approach was utilized to screen synergistic drug combinations. However, the in vitro method… read more here.
Keywords: network; drug combination; prediction; synergistic drug ... See more keywords
PO-484 Development of a two-step screening-and-confirmation approach to efficiently identify synergistic drug combinations with the PARP inhibitor niraparib
Sign Up to like & getrecommendations! Published in 2018 at "ESMO Open"
DOI: 10.1136/esmoopen-2018-eacr25.502
Abstract: Introduction Poly (ADP-ribose) polymerases (PARPs) are important players in DNA damage repair. Inhibition of PARP activity is highly effective against cancers deficient in homologous recombination repair due to, a.o., BRCA1/2 mutations. Clinically, PARP inhibitors (PARPi)… read more here.
Keywords: inhibitor; confirmation; step; drug ... See more keywords
A novel network based linear model for prioritization of synergistic drug combinations
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DOI: 10.1371/journal.pone.0266382
Abstract: Drug combination therapies can improve drug efficacy, reduce drug dosage, and overcome drug resistance in cancer treatments. Current research strategies to determine which drug combinations have a synergistic effect rely mainly on clinical or empirical… read more here.
Keywords: single drug; novel network; drug combinations; synergistic drug ... See more keywords