A Biomimetic Lubricating Nanosystem with Responsive Drug Release for Osteoarthritis Synergistic Therapy
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202203245
Abstract: Osteoarthritis (OA) is associated with lubrication failure of articular cartilage and severe inflammatory response of joint capsule. Synergistic therapy combining joint lubrication and anti‐inflammation emerges as a novel treatment of OA. In this study, bioinspired… read more here.
Keywords: synergistic therapy; drug release; responsive drug;
Mesoporous Polydopamine‐Based Nanovehicles as a Versatile Drug Loading Platform to Enable Tumor‐Sufficient Synergistic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "ChemMedChem"
DOI: 10.1002/cmdc.202200360
Abstract: The combination of photothermal therapy and chemotherapy are developing as a promising clinical strategy but it urgently needs the high exploration of intelligent multifunctional drug delivery nanovectors. In this paper, we used a versatile method… read more here.
Keywords: synergistic therapy; mesoporous polydopamine; tumor; drug ... See more keywords
A versatile photothermal vaccine based on acid-responsive glyco-nanoplatform for synergistic therapy of cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.120792
Abstract: The race is on for therapeutic agents that stop cancer. An effective vaccine offers a safe and promising approach for cancer immunotherapy. However, substantial barriers to immunotherapy in cancer vaccines include the low immunogenicity of… read more here.
Keywords: cancer; vaccine; acdex nps; synergistic therapy ... See more keywords
Glycol chitosan/iron oxide/polypyrrole nanoclusters for precise chemodynamic/photothermal synergistic therapy.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2022.01.085
Abstract: Noninvasive photothermal therapy (PTT) represents a promising direction for more modern and precise medical applications. However, PTT efficacy is still not satisfactory due to the existence of heat shock proteins (HSPs) and poorly targeted delivery.… read more here.
Keywords: polypyrrole nanoclusters; iron oxide; therapy; synergistic therapy ... See more keywords
Dual-stimuli responsive mesoporous copper (II) sulfide nanocomposite for chemo-photothermal synergistic therapy
Sign Up to like & getrecommendations! Published in 2020 at "Microporous and Mesoporous Materials"
DOI: 10.1016/j.micromeso.2020.110228
Abstract: Abstract A combination of chemo-photothermal therapy has recently emerged as a great potential cancer treatment due to enhanced therapeutic efficacy. Herein, we present a novel nanocomposite for chemo-photothermal synergistic therapy. The glutathione (GSH)-responsive mesoporous silica-coated… read more here.
Keywords: photothermal synergistic; dual stimuli; chemo photothermal; synergistic therapy ... See more keywords
Glycopolymeric Photosensitizers with Cholic Acid for HepG2-Targeted Chemo-Photodynamic Synergistic Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00165
Abstract: The aggregation-caused quenching, premature drug release, and hypoxia-caused resistance of photodynamic therapy (PDT) are challenges in the design and preparation of novel porphyrin-containing photosensitizers. In this work, a series of block copolymers consisting of a… read more here.
Keywords: synergistic therapy; cholic acid; therapy; photosensitizers cholic ... See more keywords
An Endogenous H2S-Activated Nanoplatform for Triple Synergistic Therapy of Colorectal Cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c01346
Abstract: Overproduced hydrogen sulfide (H2S) is a highly potential target for precise colorectal cancer (CRC) therapy; herein, a novel 5-Fu/Cur-P@HMPB nanomedicine is developed by coencapsulation of the natural anticancer drug curcumin (Cur) and the clinical chemotherapeutic… read more here.
Keywords: synergistic therapy; therapy; triple synergistic; colorectal cancer ... See more keywords
Use of pH-Active Catechol-Bearing Polymeric Nanogels with Glutathione-Responsive Dissociation to Codeliver Bortezomib and Doxorubicin for the Synergistic Therapy of Cancer.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c10328
Abstract: Synergistic therapy holds promising potential in cancer treatment. Here, the inclusion of catechol moieties, a disulfide cross-linked structure, and pendent carboxyl into the network of polymeric nanogels with glutathione (GSH)-responsive dissociation and pH-sensitive release is… read more here.
Keywords: nanogels glutathione; polymeric nanogels; cancer; synergistic therapy ... See more keywords
Hofmeister Effect-Based T1-T2 Dual-Mode MRI and Enhanced Synergistic Therapy of Tumor.
Sign Up to like & getrecommendations! Published in 2022 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c15295
Abstract: The imaging resolution of magnetic resonance imaging (MRI) is influenced by many factors. The development of more effective MRI contrast agents (CAs) is significant for early tumor detection and radical treatment, albeit challenging. In this… read more here.
Keywords: tumor; mri; synergistic therapy; hofmeister effect ... See more keywords
Hyperthermia and Controllable Free Radicals Co-Enhanced Synergistic Therapy in Hypoxia Enabled by Near-Infrared-II Light Irradiation.
Sign Up to like & getrecommendations! Published in 2019 at "ACS nano"
DOI: 10.1021/acsnano.9b05985
Abstract: Tumor cells metabolism and tumor blood vessels proliferation represent in a distinctive way compared to normal cells. The resulting tumor microenvironment will presents a characteristic of hypoxia, which greatly limits the generation of oxygen free… read more here.
Keywords: free radicals; near infrared; synergistic therapy; therapy ... See more keywords
Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b01641
Abstract: Due to the vast differences in chemical properties among small molecule drugs, nucleotide drugs, and superparamagnetic iron oxide nanocubes (SPIONs), such as charge and hydrophobicity, entrapment of these within a single carrier for traceable synergistic… read more here.
Keywords: drug loading; synergistic therapy; positively charged; charged polyprodrug ... See more keywords