Fetal hematogenous routing of a donor hematopoietic stem cell line in a healthy syngeneic model of transamniotic stem cell therapy.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of pediatric surgery"
DOI: 10.1016/j.jpedsurg.2021.02.035
Abstract: BACKGROUND/PURPOSE In utero administration of hematopoietic stem cells (HSCs) has a variety of actual or potential clinical applications but is hindered by invasive, morbid administration techniques. We sought to determine whether donor HSCs could reach… read more here.
Keywords: syngeneic; stem cell; model transamniotic; hematopoietic stem ... See more keywords
Abstract C005: Arylsulfatase B inhibits progression of malignant melanoma by COP1-mediated apoptosis in syngeneic and humanized mouse models
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.targ-25-c005
Abstract: The enzyme Arylsulfatase B (ARSB; N-acetylgalactosamine-4-sulfatase) removes the 4-sulfate group at the non-reducing end of chondroitin 4-sulfate (C4S) and is required for C4S degradation in mammalian cells. Congenital, inactivating mutations of ARSB are the cause… read more here.
Keywords: malignant melanoma; cop1; arsb; arylsulfatase ... See more keywords
Abstract 2158: Inhibition of NFkB restores tamoxifen responsiveness in resistant estrogen receptor positive breast cancer in a syngeneic mouse model
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-2158
Abstract: Breast cancer is responsible for 23% of new cancer cases per year worldwide and is the most frequently diagnosed cancer in women. Approximately 75% of breast cancers express the estrogen receptor (ER), and are subsequently… read more here.
Keywords: syngeneic; breast cancer; resistance; cancer ... See more keywords
Abstract LB-319: Establishment of automated multiplex immunofluorescence T-cell panel for baseline screening of syngeneic mouse models and evaluation of T-cell infiltration in A20 syngeneic tumors treated with TAK-981, a first-in-class SUMO inhibitor
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-lb-319
Abstract: Mouse syngeneic tumor models play a crucial role in the translationally oriented process of assessing the preclinical activity and mechanism of action of emerging novel immunotherapies and immunotherapy combinations. Recent advancements in fluorescent multiplex technology… read more here.
Keywords: sumo inhibitor; tak 981; syngeneic; mouse ... See more keywords
Abstract 708: Targeting aurora kinase B (AURKB) as a radiosensitizing strategy in syngeneic models of triple negative breast cancer (TNBC)
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-708
Abstract: Purpose: Triple negative breast cancer (TNBC) is an aggressive breast cancer (BC) subtype with few treatment options. Radiation therapy (RT) is a mainstay therapy for the treatment of BC, but local recurrence following RT therapy… read more here.
Keywords: cancer; aurkb inhibition; syngeneic; triple negative ... See more keywords
Abstract 5166: Increasing translatability of syngeneic mouse models of cancer through the application of human-validated, clinically relevant gene expression-based measurements of the tumor immune microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5166
Abstract: Syngeneic mouse models serve as invaluable tools in preclinical research. Implanting cancer cells into immunocompetent mice allows immunotherapy responses to be assessed in a physiologically relevant setting. To further improve the translatability of syngeneic models,… read more here.
Keywords: cancer; tumor; human validated; syngeneic ... See more keywords
Preclinical Platform Using a Triple-negative Breast Cancer Syngeneic Murine Model to Evaluate Immune Checkpoint Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "AntiCancer Research"
DOI: 10.21873/anticanres.16137
Abstract: Background/Aim: To evaluate the feasibility of syngeneic mouse models of breast cancer by analyzing the efficacy of immune checkpoint inhibitors (ICIs) and potential predictive biomarkers. Materials and Methods: To establish the murine triple-negative breast cancer… read more here.
Keywords: syngeneic; preclinical platform; breast cancer; model ... See more keywords
Model-Based Anticancer Effect of Botulinum Neurotoxin Type A1 on Syngeneic Melanoma Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.793349
Abstract: In recent, Botulinum Neurotoxin A1 (BoNT/A1) has been suggested as a potential anticancer agent due to neuronal innervation in tumor cells. Although potential BoNT/A1’s mechanism of action for the tumor suppression has been gradually revealed… read more here.
Keywords: syngeneic; anticancer effect; model; bont ... See more keywords