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   Articles with "synnotch" as a keyword



CXCL10 encoding synNotch T cells enhance anti-tumor immune responses without systemic side effect.

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recommendations! Published in 2020 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2020.11.002

Abstract: Modifying T cells to attack tumors using engineered chimeric receptors display powerful new therapeutic capabilities. Unfortunately, the effectiveness of therapeutic T cells is limited due to the inherent T cell responses: certain facets of endogenous… read more here.

Keywords: cxcl10 encoding; anti tumor; synnotch cells; synnotch ... See more keywords

Engineering a Programmed Death-Ligand 1-Targeting Monobody Via Directed Evolution for SynNotch-Gated Cell Therapy

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recommendations! Published in 2024 at "ACS Nano"

DOI: 10.1021/acsnano.4c01597

Abstract: Programmed death-ligand 1 (PD-L1) is a promising target for cancer immunotherapy due to its ability to inhibit T cell activation; however, its expression on various noncancer cells may cause on-target off-tumor toxicity when designing PD-L1-targeting… read more here.

Keywords: synnotch; pdbody; tumor; car ... See more keywords

SynNotch-Programmed Macrophages for Cancerous Cell Detection and Sensing.

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recommendations! Published in 2024 at "ACS sensors"

DOI: 10.1021/acssensors.4c01997

Abstract: Synthetic Notch (synNotch) receptors have enabled mammalian cells to sense extracellular ligands and respond by activating user-prescribed transcriptional programs. Based on the synNotch system, we describe a cell-based in vivo sensor for cancerous cell detection.… read more here.

Keywords: cancer; synnotch; cell; synnotch programmed ... See more keywords

Functional Comparison between Endogenous and Synthetic Notch Systems

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recommendations! Published in 2022 at "ACS Synthetic Biology"

DOI: 10.1021/acssynbio.2c00247

Abstract: The Notch pathway converts receptor-ligand interactions at the cell surface into a transcriptional response in the receiver cell. In recent years, synthetic Notch systems (SynNotch) that respond to different inputs and transduce different transcriptional responses… read more here.

Keywords: synnotch; ligand icd; notch systems; synthetic notch ... See more keywords

SynNotch CAR-T cell, when synthetic biology and immunology meet again

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recommendations! Published in 2025 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2025.1545270

Abstract: Cancer immunotherapy has been transformed by chimeric antigen receptor (CAR) T-cell treatment, which has shown groundbreaking results in hematological malignancies. However, its application in solid tumors remains a formidable challenge due to immune evasion, tumor… read more here.

Keywords: synnotch; immunology; car cell; biology ... See more keywords

Augmenting the Antitumor Efficacy of Natural Killer Cells via SynNotch Receptor Engineering for Targeted IL-12 Secretion

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recommendations! Published in 2024 at "Current Issues in Molecular Biology"

DOI: 10.3390/cimb46040183

Abstract: Natural killer (NK) cells are crucial components of innate immunity, known for their potent tumor surveillance abilities. Chimeric antigen receptors (CARs) have shown promise in cancer targeting, but optimizing CAR designs for NK cell functionality… read more here.

Keywords: receptor; synnotch; killer cells; natural killer ... See more keywords