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Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100867
Abstract: Summary SynNotch receptor technology is a versatile tool that uses the regulatory notch core portion with an extracellular scFv and an intracellular transcription factor that enables to program customized input and output functions in mammalian…
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Keywords:
synnotch receptor;
cellular biosensors;
antiviral responses;
engineering cellular ... See more keywords
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Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01448
Abstract: IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch)…
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Keywords:
synnotch receptor;
il12;
car;
nk92 cells ... See more keywords