Engineering Cellular Biosensors with Customizable Antiviral Responses Targeting Hepatitis B Virus
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.100867
Abstract: Summary SynNotch receptor technology is a versatile tool that uses the regulatory notch core portion with an extracellular scFv and an intracellular transcription factor that enables to program customized input and output functions in mammalian… read more here.
Keywords: synnotch receptor; cellular biosensors; antiviral responses; engineering cellular ... See more keywords
Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.01448
Abstract: IL12 is an immune-stimulatory cytokine for key immune cells including T cells and NK cells. However, systemic administration of IL12 has serious side effects that limit its clinical application in patients. Recently, synthetic Notch (synNotch)… read more here.
Keywords: synnotch receptor; il12; car; nk92 cells ... See more keywords
Augmenting the Antitumor Efficacy of Natural Killer Cells via SynNotch Receptor Engineering for Targeted IL-12 Secretion
Sign Up to like & getrecommendations! Published in 2024 at "Current Issues in Molecular Biology"
DOI: 10.3390/cimb46040183
Abstract: Natural killer (NK) cells are crucial components of innate immunity, known for their potent tumor surveillance abilities. Chimeric antigen receptors (CARs) have shown promise in cancer targeting, but optimizing CAR designs for NK cell functionality… read more here.
Keywords: receptor; synnotch; killer cells; natural killer ... See more keywords