Fitness benefits of a synonymous substitution in an ancient EF-Tu gene depend on the genetic background
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bacteriology"
DOI: 10.1128/jb.00329-23
Abstract: ABSTRACT Synonymous mutations are changes to DNA sequence, which occur within translated genes but which do not affect the protein sequence. Although often referred to as silent mutations, evidence suggests that synonymous mutations can affect… read more here.
Keywords: synonymous mutations; gene; genetic background; synonymous mutation ... See more keywords
A synonymous mutation in PI4KA impacts the transcription and translation process of gene expression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.987666
Abstract: Phosphatidylinositol-4-kinase alpha (PI4KIIIα), encoded by the PI4KA gene, can synthesize phosphatidylinositol-4-phosphate (PI-4-P), which serves as a specific membrane marker and is instrumental in signal transduction. PI4KA mutations can cause autosomal recessive diseases involving neurological, intestinal,… read more here.
Keywords: synonymous mutation; pi4ka impacts; mutation pi4ka; mutation ... See more keywords
A synonymous mutation of rs1137070 cause the mice Maoa gene transcription and translation to decrease
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2024.1406708
Abstract: The Monoamine Oxidase-A (MAOA) EcoRV polymorphism (rs1137070) is a unique synonymous mutation (c.1409 T > C) within the MAOA gene, which plays a crucial role in Maoa gene expression and function. This study aimed to explore the relationship… read more here.
Keywords: rs1137070; maoa; maoa gene; expression ... See more keywords