Non-synonymous mutations of SARS-CoV-2 leads epitope loss and segregates its variants
Sign Up to like & getrecommendations! Published in 2020 at "Microbes and Infection"
DOI: 10.1016/j.micinf.2020.10.004
Abstract: The non-synonymous mutations of SARS-CoV-2 isolated from across the world have been identified during the last few months. The surface glycoprotein spike of SARS-CoV-2 forms the most important hotspot for amino acid alterations followed by… read more here.
Keywords: mutations sars; synonymous mutations; loss; epitope loss ... See more keywords
Double synonymous mutations in exon 9 of the Cullin3 gene restore exon inclusion by abolishing hnRNPs inhibition.
Sign Up to like & getrecommendations! Published in 2022 at "Human molecular genetics"
DOI: 10.1093/hmg/ddac148
Abstract: All mutations in exon 9 of the Cullin3 gene associated with pseudohypoaldosteronism type II (PHA II) contribute to exon skipping to different degrees, but the specific molecular mechanism of this aberrant splicing is still unclear.… read more here.
Keywords: cullin3 gene; double synonymous; mutations exon; synonymous mutations ... See more keywords
The High Mutational Sensitivity of ccdA Antitoxin Is Linked to Codon Optimality
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msac187
Abstract: Deep mutational scanning studies suggest that synonymous mutations are typically silent and that most exposed, non active-site residues are tolerant to mutations. Here we show that the ccdA antitoxin component of the E.coli ccdAB toxin-antitoxin… read more here.
Keywords: mutational sensitivity; ccda antitoxin; high mutational; antitoxin ... See more keywords
Codon-Resolution Analysis Reveals a Direct and Context-Dependent Impact of Individual Synonymous Mutations on mRNA Level
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology and Evolution"
DOI: 10.1093/molbev/msx229
Abstract: Abstract Codon usage bias (CUB) refers to the observation that synonymous codons are not used equally frequently in a genome. CUB is stronger in more highly expressed genes, a phenomenon commonly explained by stronger natural… read more here.
Keywords: individual synonymous; cub; synonymous mutations; level ... See more keywords
The importance of mRNA structure in determining the pathogenicity of synonymous and non‐synonymous mutations in haemophilia
Sign Up to like & getrecommendations! Published in 2017 at "Haemophilia"
DOI: 10.1111/hae.13107
Abstract: Mutational analysis is commonly used to support the diagnosis and management of haemophilia. This has allowed for the generation of large mutation databases which provide unparalleled insight into genotype–phenotype relationships. Haemophilia is associated with inversions,… read more here.
Keywords: synonymous non; synonymous mutations; mrna structure; structure determining ... See more keywords
Three new HLA class I alleles with synonymous mutations: HLA‐A*03:01:62, ‐C*07:02:82 and ‐C*12:03:42
Sign Up to like & getrecommendations! Published in 2018 at "HLA"
DOI: 10.1111/tan.13163
Abstract: Three new HLA class I alleles with synonymous mutations were identified. read more here.
Keywords: new hla; class alleles; synonymous mutations; three new ... See more keywords
Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08131-w
Abstract: Background Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. However, synonymous mutations will change the codon optimality, resulting in… read more here.
Keywords: synonymous mutations; codon optimality; might play; cancer ... See more keywords
Synonymous mutations make dramatic contributions to fitness when growth is limited by a weak-link enzyme
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Genetics"
DOI: 10.1371/journal.pgen.1007615
Abstract: Synonymous mutations do not alter the specified amino acid but may alter the structure or function of an mRNA in ways that impact fitness. There are few examples in the literature, however, in which the… read more here.
Keywords: weak link; synonymous mutations; link enzyme; growth rate ... See more keywords
PredDSMC: A predictor for driver synonymous mutations in human cancers
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1164593
Abstract: Introduction: Driver mutations play a critical role in the occurrence and development of human cancers. Most studies have focused on missense mutations that function as drivers in cancer. However, accumulating experimental evidence indicates that synonymous… read more here.
Keywords: preddsmc predictor; driver synonymous; mutations human; synonymous mutations ... See more keywords
Synonymous mutations in the phosphoglycerate kinase 1 gene induce an altered response to protein misfolding in Schizosaccharomyces pombe
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1074741
Abstract: Background Proteostasis refers to the processes that regulate the biogenesis, folding, trafficking, and degradation of proteins. Any alteration in these processes can lead to cell malfunction. Protein synthesis, a key proteostatic process, is highly-regulated at… read more here.
Keywords: phosphoglycerate kinase; protein misfolding; synonymous mutations; schizosaccharomyces pombe ... See more keywords