Nonsynonymous, synonymous and nonsense mutations in human cancer-related genes undergo stronger purifying selections than expectation
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DOI: 10.1186/s12885-019-5572-x
Abstract: BackgroundNonsynonymous mutations change the protein sequences and are frequently subjected to natural selection. The same goes for nonsense mutations that introduce pre-mature stop codons into CDSs (coding sequences). Synonymous mutations, however, are intuitively thought to… read more here.
Keywords: synonymous nonsense; cancer related; nonsynonymous synonymous; related genes ... See more keywords