Transforming growth factor activating kinase 1 regulates extracellular matrix degrading enzymes and pain-related molecule expression following tumor necrosis factor-α stimulation of synovial cells: an in vitro study
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DOI: 10.1186/s12891-017-1648-4
Abstract: BackgroundRecent studies have suggested that the tumor necrosis factor-α (TNF-α) pathway is a potential target for the management of osteoarthritis (OA). Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is essential in several cytokine-mediated cascades, including… read more here.
Keywords: fold fold; extracellular matrix; expression; fold respectively ... See more keywords
HTR2B and SLC5A3 Are Specific Markers in Age-Related Osteoarthritis and Involved in Apoptosis and Inflammation of Osteoarthritis Synovial Cells
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DOI: 10.3389/fmolb.2021.691602
Abstract: Objective: Osteoarthritis (OA) is a heterogeneous age-related disease, which is badly difficult to cure due to its complex regulatory networks of pathogenesis. This study explored OA-specific genes in synovial tissues and validated their roles on… read more here.
Keywords: age related; htr2b slc5a3; apoptosis inflammation; synovial cells ... See more keywords
Single-cell analysis reveals that Jinwu Gutong capsule attenuates the inflammatory activity of synovial cells in osteoarthritis by inhibiting AKR1C3
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DOI: 10.3389/fphys.2022.1031996
Abstract: Jinwu Gutong capsule (JGC) is a traditional Chinese medicine formula for the treatment of osteoarthritis (OA). Synovitis is a typical pathological change in OA and promotes disease progression. Elucidating the therapeutic mechanism of JGC is… read more here.
Keywords: inhibiting akr1c3; synovitis; gutong capsule; jinwu gutong ... See more keywords
DHA Induces Cell Death through the Production of ROS and the Upregulation of CHOP in Fibroblast-like Synovial Cells from Human Rheumatoid Arthritis Patients
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DOI: 10.3390/ijms24021734
Abstract: Rheumatoid arthritis (RA) is an inflammatory disease marked by a massive proliferation of synovial cells in the joints. In this study, we investigated the pro-apoptotic effects of docosahexaenoic acid (DHA) in human fibroblast-like synovial cells… read more here.
Keywords: chop; rheumatoid arthritis; like synovial; fibroblast like ... See more keywords
Jietacin Derivative Inhibits TNF-α-Mediated Inflammatory Cytokines Production via Suppression of the NF-κB Pathway in Synovial Cells
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DOI: 10.3390/ph16010005
Abstract: Synovial inflammation plays a central role in joint destruction and pain in osteoarthritis (OA). The NF-κB pathway plays an important role in the inflammatory process and is activated in OA. A previous study reported that… read more here.
Keywords: jietacin derivative; inflammatory cytokines; production; tnf mediated ... See more keywords
Ginkgolide J protects human synovial cells SW982 via suppression of p38-dependent production of pro-inflammatory mediators
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DOI: 10.3892/mmr.2021.12194
Abstract: Fibroblast-like synoviocytes (FLS) in the synovial lining play a key role in the pathological process of rheumatoid arthritis (RA), which produce pro-inflammatory mediators to perpetuate inflammation and proteases to contribute to cartilage destruction. Ginkgolide J… read more here.
Keywords: production pro; inflammatory mediators; synovial cells; pro inflammatory ... See more keywords