CCN2 Facilitates IL‐17 Production and Osteoclastogenesis in Human Osteoarthritis Synovial Fibroblasts by Inhibiting miR‐655 Expression
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4661
Abstract: Osteoarthritis (OA) is associated with extensive upregulation of osteoclastogenesis and subsequent bone breakdown. The CCN family protein connective tissue growth factor (CCN2, also called CCN2) enhances inflammatory cytokine production in OA disease. The cytokine interleukin… read more here.
Keywords: osteoclastogenesis; mir 655; expression; production ... See more keywords
DPP4 reduces proinflammatory cytokine production in human rheumatoid arthritis synovial fibroblasts.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30494
Abstract: Rheumatoid arthritis (RA) is an autoimmune disorder that is characterized by increasing levels of proinflammatory cytokines. The ubiquitous enzyme dipeptidyl peptidase-4 (DPP4, also known as CD26) regulates different immune disorders, although the effects of DPP4… read more here.
Keywords: synovial fibroblasts; cytokine production; rheumatoid arthritis; proinflammatory cytokine ... See more keywords
Dickkopf-1 perpetuated synovial fibroblast activation and synovial angiogenesis in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Rheumatology"
DOI: 10.1007/s10067-021-05766-9
Abstract: Dickkopf-1 (Dkk-1), a regulatory molecule of the Wnt pathway, is elevated and leads to bone resorption in patients with RA. This study is aimed to investigate the contribution of Dkk-1 to synovial inflammation and synovial… read more here.
Keywords: angiogenesis; inflammatory cytokines; expression; synovial fibroblasts ... See more keywords
Upregulated KAT7 in synovial fibroblasts promotes Th17 cell differentiation and infiltration in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.05.143
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease involving multiple cellular participants, of which synovial fibroblasts (SFs) are tightly connected with the development and progression of RA. Here, we provide evidence confirming that KAT7, an… read more here.
Keywords: cell differentiation; synovial fibroblasts; rheumatoid arthritis; th17 cell ... See more keywords
Mast cell chymase in synovial fluid of collagen-induced-arthritis rats regulates gelatinase release and promotes synovial fibroblasts proliferation via FAK/p21 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.04.121
Abstract: Mast cells (MCs) were accumulated in synovial tissue of rheumatoid arthritis (RA) patients. MC activation releases numerous mediators including MC-chymase. Synovial fibroblast shows a dramatic hyperplasia in RA articular cavity, but the effects of MC-chymase… read more here.
Keywords: synovial fibroblasts; chymase synovial; synovial fibroblast; arthritis ... See more keywords
MicroRNA-146a governs fibroblast activation and joint pathology in arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2017.05.006
Abstract: Synovial fibroblasts are key cells orchestrating the inflammatory response in arthritis. Here we demonstrate that loss of miR-146a, a key epigenetic regulator of the innate immune response, leads to increased joint destruction in a TNF-driven… read more here.
Keywords: mir 146a; response; pathology; microrna 146a ... See more keywords
Molecular insights into the differences in anti‐inflammatory activities of green tea catechins on IL‐1&bgr; signaling in rheumatoid arthritis synovial fibroblasts
Sign Up to like & getrecommendations! Published in 2017 at "Toxicology and Applied Pharmacology"
DOI: 10.1016/j.taap.2017.05.016
Abstract: &NA; In this study, we found that catechins found in green tea (EGCG, EGC, and EC) differentially interfere with the IL‐1&bgr; signaling pathway which regulates the expression of pro‐inflammatory mediators (IL‐6 and IL‐8) and Cox‐2… read more here.
Keywords: anti inflammatory; green tea; bgr signaling; tea ... See more keywords
Engineered Platelet Microparticle-Membrane Camouflaged Nanoparticles for Targeting the Golgi Apparatus of Synovial Fibroblasts to Attenuate Rheumatoid Arthritis.
Sign Up to like & getrecommendations! Published in 2022 at "ACS nano"
DOI: 10.1021/acsnano.2c06584
Abstract: Synovial fibroblasts in rheumatoid arthritis (RA) joints mediate synovial hyperplasia, progressive joint destruction, and the potential spread of disease between joints by producing multiple pathogenic proteins. Here, we deliver all-trans retinoic acid (ATRA) to selectively… read more here.
Keywords: synovial fibroblasts; gol pmmnps; golgi apparatus;
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
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DOI: 10.1038/s41467-020-14421-x
Abstract: Rheumatoid arthritis affects individuals commonly during the most productive years of adulthood. Poor response rates and high costs associated with treatment mandate the search for new therapies. Here we show that targeting a specific G-protein… read more here.
Keywords: therapeutic senescence; senescence via; activation; synovial fibroblasts ... See more keywords
TNF antagonist sensitizes synovial fibroblasts to ferroptotic cell death in collagen-induced arthritis mouse models
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DOI: 10.1038/s41467-021-27948-4
Abstract: Ferroptosis is a nonapoptotic cell death process that requires cellular iron and the accumulation of lipid peroxides. In progressive rheumatoid arthritis (RA), synovial fibroblasts proliferate abnormally in the presence of reactive oxygen species (ROS) and… read more here.
Keywords: ferroptosis; arthritis; mouse; cell death ... See more keywords
Familial Mediterranean fever-related miR-197-3p targets IL1R1 gene and modulates inflammation in monocytes and synovial fibroblasts
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-020-80097-4
Abstract: Familial Mediterranean fever (FMF); is an autosomal recessively inherited autoinflammatory disease caused by the mutations in the Mediterranean Fever ( MEFV ) gene. Recent studies have shown that epigenetic control mechanisms, particularly non-coding RNAs, may… read more here.
Keywords: il1r1 gene; familial mediterranean; mir 197; synovial fibroblasts ... See more keywords