WNT10A induces apoptosis of senescent synovial resident stem cells through WNT/calcium pathway-mediated HDAC5 phosphorylation in OA joints.
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DOI: 10.1016/j.bone.2021.116006
Abstract: Recently, the accumulation of senescent cells (SnCs) within joints was found to promote osteoarthritis (OA) progression. Our previous study found that Wnt proteins, especially Wnt10a, have marked effects on cellular senescence and joint health. However,… read more here.
Keywords: synovial resident; stem cells; hdac5 phosphorylation; wnt calcium ... See more keywords