Increased cytokine levels and histological changes in cartilage, synovial cells and synovial fluid after malleolar fractures.
Sign Up to like & getrecommendations! Published in 2017 at "Injury"
DOI: 10.1016/s0020-1383(17)30772-6
Abstract: BACKGROUND Malleolar fractures are among the most common fractures in the human skeleton with a high risk of later development of post-traumatic osteoarthritis (OA). The acute ankle injury initiates a sequence of events potentially leading… read more here.
Keywords: synovial tissue; malleolar fractures; tissue; synovial fluid ... See more keywords
Immunogenic HLA-DR-Presented Self-Peptides Identified Directly from Clinical Samples of Synovial Tissue, Synovial Fluid, or Peripheral Blood in Patients with Rheumatoid Arthritis or Lyme Arthritis.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.6b00386
Abstract: Human leukocyte antigen-antigen D related (HLA-DR) molecules are highly expressed in synovial tissue (ST), the target of the immune response in chronic inflammatory forms of arthritis. Here, we used LC-MS/MS to identify HLA-DR-presented self-peptides in… read more here.
Keywords: synovial tissue; hla presented; self peptides; presented self ... See more keywords
Synovial tissue research: a state-of-the-art review
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DOI: 10.1038/nrrheum.2017.115
Abstract: The synovium is the major target tissue of inflammatory arthritides such as rheumatoid arthritis. The study of synovial tissue has advanced considerably throughout the past few decades from arthroplasty and blind needle biopsy to the… read more here.
Keywords: tissue research; synovial tissue; tissue; research state ... See more keywords
Next-generation analysis of synovial tissue architecture
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DOI: 10.1038/s41584-019-0357-9
Abstract: The synovium is the main target tissue of inflammatory arthritides such as rheumatoid arthritis and psoriatic arthritis. In 2019, new technologies for examining the molecular characteristics of specific cell subsets have enabled advances in our… read more here.
Keywords: analysis; synovial tissue; generation analysis; tissue ... See more keywords
Comprehensive Expression Analysis of microRNAs and mRNAs in Synovial Tissue from a Mouse Model of Early Post-Traumatic Osteoarthritis
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DOI: 10.1038/s41598-017-17545-1
Abstract: To better understand the molecular processes involved in driving osteoarthritis disease progression we characterized expression profiles of microRNAs (miRNA) and mRNAs in synovial tissue from a post-traumatic OA mouse model. OA was induced in 10–12… read more here.
Keywords: post traumatic; synovial tissue; mrnas synovial; expression ... See more keywords
Synovial tissue transcriptomes of long-standing rheumatoid arthritis are dominated by activated macrophages that reflect microbial stimulation
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DOI: 10.1038/s41598-020-64431-4
Abstract: Advances in microbiome research suggest involvement in chronic inflammatory diseases such as rheumatoid arthritis (RA). Searching for initial trigger(s) in RA, we compared transcriptome profiles of highly inflamed RA synovial tissue (RA-ST) and osteoarthritis (OA)-ST… read more here.
Keywords: activated macrophages; synovial tissue; gene patterns; rheumatoid arthritis ... See more keywords
Synovial tissue‐derived extracellular vesicles induce chondrocyte inflammation and degradation via NF‐κB signalling pathway: An in vitro study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17227
Abstract: Osteoarthritis (OA) is a whole‐joint disease characterized by synovial inflammation and cartilage degeneration. However, the relationship between synovial inflammation and cartilage degeneration remains unclear. The modified Hulth's method was adopted to establish a knee OA… read more here.
Keywords: inflammation; tissue derived; synovial tissue; degradation ... See more keywords
Cytokines in temporomandibular joint synovial fluid and tissue in relation to inflammation
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DOI: 10.1111/joor.13321
Abstract: Abstract Background Synovial tissue is known to be the origin of inflammation in joint disease. Despite this, synovial fluid is the main biological specimen of choice in temporomandibular joint (TMJ) inflammation and pathology biomarker research.… read more here.
Keywords: inflammation; synovial tissue; tissue; synovial fluid ... See more keywords
THU0079 Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.3379
Abstract: Background We have previously reported that adiponectin (AD), an adipokine that is secreted by adipocytes, correlates closely with progressive bone erosion in rheumatoid arthritis (RA). The exact mechanism of AD towards promoting joint destruction remain… read more here.
Keywords: synovial tissue; erosion; expression; bone erosion ... See more keywords
AB0227 Transcriptional profiling of synovial macrophages using minimally invasive ultrasound-guided synovial biopsies in rheumatoid arthritis
Sign Up to like & getrecommendations! Published in 2018 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2018-eular.7594
Abstract: Background Despite the many therapies for patients with rheumatoid arthritis (RA), there is little information to guide selection of the most effective treatment for an individual patient. Forty-sixty percent of patients with RA respond (defined… read more here.
Keywords: response; synovial tissue; tissue; rheumatoid arthritis ... See more keywords
Enrichment of polyfunctional T cells in PsA synovial tissue. Response to: 'Polyfunctional TEM cells in psoriatic arthritis synovium skewed towards Th17 cells' by Raychaudhuri et al.
Sign Up to like & getrecommendations! Published in 2020 at "Annals of the rheumatic diseases"
DOI: 10.1136/annrheumdis-2019-216814
Abstract: We read with interest the research letter by Raychaudhuri et al , which examines the frequencies of cytokine producing CD4+ memory T cells in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) synovial fluid mononuclear cells… read more here.
Keywords: psoriatic arthritis; synovial tissue; th17 cells; cells psoriatic ... See more keywords