Suberoylanilide Hydroxamic Acid Attenuates Interleukin-1β-Induced Interleukin-6 Upregulation by Inhibiting the Microtubule Affinity-Regulating Kinase 4/Nuclear Factor-κB Pathway in Synovium-Derived Mesenchymal Stem Cells from the Temporomandibular Joint
Sign Up to like & getrecommendations! Published in 2020 at "Inflammation"
DOI: 10.1007/s10753-020-01204-1
Abstract: Synovium-derived mesenchymal stem cells (SMSCs) can migrate to the site of destroyed condylar cartilage and differentiate into chondrocytes to repair temporomandibular joint (TMJ) damage. Interleukin (IL)-1β-induced IL-6 secretion has been shown to inhibit the chondrogenic… read more here.
Keywords: secretion; derived mesenchymal; smscs; synovium ... See more keywords
A tool for evaluating novel osteoarthritis therapies using multivariate analyses of human cartilage-synovium explant co-culture.
Sign Up to like & getrecommendations! Published in 2021 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2021.09.007
Abstract: OBJECTIVE There is a need to incorporate multiple tissues into in vitro OA models to evaluate novel therapeutics. This approach is limited by inherent donor variability. We present an optimized research tool: a human OA… read more here.
Keywords: synovium; tool; cartilage synovium; human cartilage ... See more keywords
Precursors of ‘bad’ osteoclasts identified in arthritis
Sign Up to like & getrecommendations! Published in 2019 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-019-0362-z
Abstract: volume 16 | FeBRuARY 2020 | 63 the cells expressed FOXM1 and had a high osteoclasto genic potential Osteoclasts are important for both homeostatic bone remodelling in health and pathological bone erosion in rheumatoid arthritis… read more here.
Keywords: homeostatic bone; synovium; bone remodelling; bone ... See more keywords
Recapitulating monocyte extravasation to the synovium in an organotypic microfluidic model of the articular joint
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DOI: 10.1088/1758-5090/ac0c5e
Abstract: The synovium of osteoarthritis (OA) patients can be characterized by an abnormal accumulation of macrophages originating from extravasated monocytes. Since targeting monocyte extravasation may represent a promising therapeutic strategy, our aim was to develop an… read more here.
Keywords: synovium; model; monocyte extravasation; extravasation ... See more keywords
Protective Effect of Normal Synovium on Damaged Cartilage
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DOI: 10.1177/2325967117s00337
Abstract: Objectives: Traumatic joint injury results in an acute inflammatory response. If uncontrolled, this can progress to chronic inflammation, which can expedite the onset of post-traumatic osteoarthritis (PTOA). Normal synovium plays an important protective role for… read more here.
Keywords: damaged cartilage; normal synovium; synovium; group ... See more keywords
Canine mesenchymal stem cells from synovium have a higher chondrogenic potential than those from infrapatellar fat pad, adipose tissue, and bone marrow
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DOI: 10.1371/journal.pone.0202922
Abstract: Osteoarthritis (OA), a common chronic joint disorder in both humans and canines, is characterized by a progressive loss of articular cartilage. Canines can serve as an animal model of OA for human medicine, and this… read more here.
Keywords: fat pad; medicine; canine; synovium ... See more keywords
Proteolysis and cartilage development are activated in the synovium after surgical induction of post traumatic osteoarthritis
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DOI: 10.1371/journal.pone.0229449
Abstract: Anterior cruciate ligament (ACL) transection surgery in the minipig induces post-traumatic osteoarthritis (PTOA) in a pattern similar to that seen in human patients after ACL injury. Prior studies have reported the presence of cartilage matrix-degrading… read more here.
Keywords: proteolysis; synovium; acl transection; cartilage development ... See more keywords
Infrapatellar Fat Pad/Synovium Complex in Early-Stage Knee Osteoarthritis: Potential New Target and Source of Therapeutic Mesenchymal Stem/Stromal Cells
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00860
Abstract: The infrapatellar fat pad (IFP) has until recently been viewed as a densely vascular and innervated intracapsular/extrasynovial tissue with biomechanical roles in the anterior compartment of the knee. Over the last decade, secondary to the… read more here.
Keywords: fat pad; source; synovium; target ... See more keywords
Two Main Cellular Components in Rheumatoid Arthritis: Communication Between T Cells and Fibroblast-Like Synoviocytes in the Joint Synovium
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.922111
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease that endangers the health of approximately 1% of the global population. Current RA medications on the market mainly include non-steroidal anti-inflammatory drugs, biological agents, and disease-modifying drugs.… read more here.
Keywords: rheumatoid arthritis; like synoviocytes; two main; fibroblast like ... See more keywords
Bridging Insights From Lymph Node and Synovium Studies in Early Rheumatoid Arthritis
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DOI: 10.3389/fmed.2021.820232
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology characterized by inflammation of the peripheral synovial joints leading to pannus formation and bone destruction. Rheumatoid Factor (RF) and anti-citrullinated protein antibodies (ACPA) are… read more here.
Keywords: inflammation; rheumatoid arthritis; lymph nodes; lymph node ... See more keywords
Histopathology of Psoriatic Arthritis Synovium—A Narrative Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Medicine"
DOI: 10.3389/fmed.2022.860813
Abstract: Psoriatic arthritis (PsA) is a phenotypically heterogeneous chronic inflammatory disease associated to type I major histocompatibility complex alleles whose complex pathogenesis is still not completely understood. The psoriatic synovium shares general features of chronic inflammation… read more here.
Keywords: disease; psoriatic arthritis; histopathology psoriatic; synovium ... See more keywords