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   Articles with "syntaxin" as a keyword



Tomosyn guides SNARE complex formation in coordination with Munc18 and Munc13

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recommendations! Published in 2018 at "FEBS Letters"

DOI: 10.1002/1873-3468.13018

Abstract: As a SNARE binding protein, tomosyn has been reported to negatively regulate synaptic exocytosis via arresting syntaxin‐1 and SNAP‐25 into a nonfusogenic product that precludes synaptobrevin‐2 entry, raising the question how the assembly of the… read more here.

Keywords: snare; snare complex; syntaxin; munc18 ... See more keywords

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

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recommendations! Published in 2025 at "Advanced Science"

DOI: 10.1002/advs.202507210

Abstract: SYNTAXIN 12/13 (STX12), a member of the syntaxin protein family enriched in the brain and heart, plays important roles in vesicle recycling. Currently, the role of STX12 in cardiovascular physiology remains unclear. Using zebrafish and… read more here.

Keywords: syntaxin; serca; heart; stx12 ... See more keywords

Crucial Role of Postsynaptic Syntaxin 4 in Mediating Basal Neurotransmission and Synaptic Plasticity in Hippocampal CA1 Neurons.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.05.026

Abstract: Trafficking of neurotransmitter receptors on postsynaptic membranes is critical for basal neurotransmission and synaptic plasticity, yet the underlying mechanisms remain elusive. Here, we investigated the role of syntaxin 4 in postsynaptic hippocampal CA1 neurons by… read more here.

Keywords: synaptic plasticity; syntaxin; neurotransmission synaptic; basal neurotransmission ... See more keywords

Phosphorylation of Syntaxin 17 by TBK1 Controls Autophagy Initiation.

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recommendations! Published in 2019 at "Developmental cell"

DOI: 10.1016/j.devcel.2019.01.027

Abstract: Syntaxin 17 (Stx17) has been implicated in autophagosome-lysosome fusion. Here, we report that Stx17 functions in assembly of protein complexes during autophagy initiation. Stx17 is phosphorylated by TBK1 whereby phospho-Stx17 controls the formation of the… read more here.

Keywords: tbk1; atg13 fip200; autophagy initiation; syntaxin ... See more keywords

Structural remodeling of target-SNARE protein complexes by NSF enables synaptic transmission

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-025-62764-0

Abstract: Synaptic vesicles containing neurotransmitters fuse with the plasma membrane upon the arrival of an action potential at the active zone. Multiple proteins organize trans-SNARE complex assembly and priming, leading to fusion. One target membrane SNARE,… read more here.

Keywords: syntaxin; structural remodeling; snare; protein ... See more keywords

SNARE assembly enlightened by cryo-EM structures of a synaptobrevin–Munc18-1–syntaxin-1 complex

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recommendations! Published in 2022 at "Science Advances"

DOI: 10.1101/2022.03.05.483126

Abstract: Munc18-1 forms a template to recruit and organize assembly of the SNARE complex that triggers neurotransmitter release, binding first to a closed conformation of syntaxin-1 where its N-terminal region interacts with the SNARE motif, and… read more here.

Keywords: snare; cryo structures; syntaxin; complex assembly ... See more keywords

Syntaxin 1B contributes to regulation of the dopaminergic system through GABA transmission in the CNS

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recommendations! Published in 2017 at "European Journal of Neuroscience"

DOI: 10.1111/ejn.13779

Abstract: In neuronal plasma membrane, two syntaxin isoforms, HPC‐1/syntaxin 1A (STX1A) and syntaxin 1B (STX1B), are predominantly expressed as soluble N‐ethylmaleimide‐sensitive fusion attachment protein receptors, also known as t‐SNAREs. We previously reported that glutamatergic and GABAergic… read more here.

Keywords: system; transmission; cns; syntaxin ... See more keywords

Functional regulation of syntaxin-1: An underlying mechanism mediating exocytosis in neuroendocrine cells

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recommendations! Published in 2023 at "Frontiers in Endocrinology"

DOI: 10.3389/fendo.2023.1096365

Abstract: The fusion of the secretory vesicle with the plasma membrane requires the assembly of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein complexes formed by synaptobrevin, syntaxin-1, and SNAP-25. Within the pathway leading to exocytosis,… read more here.

Keywords: neuroendocrine cells; fusion; exocytosis; syntaxin ... See more keywords

Syntaxin-6, a Reliable Biomarker for Predicting the Prognosis of Patients with Cancer and the Effectiveness of Immunotherapy

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recommendations! Published in 2022 at "Cancers"

DOI: 10.3390/cancers15010027

Abstract: Simple Summary The treatment of cancer may differ on the basis of whether it is detected early or late, which determines whether the disease has spread, as well as treatment choices. Therefore, early detection is… read more here.

Keywords: stx6; syntaxin; biomarker; immunotherapy ... See more keywords