Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.12948
Abstract: Mitochondrial tubular structures are maintained by a balance between membrane fusion and fission that is regulated by various factors, including Drp1 and mitofusin/fzo‐1. Here we report the role of cardiolipin (CL) synthase in the regulation… read more here.
Keywords: mitochondrial morphology; cardiolipin synthase; synthase; inactivation cardiolipin ... See more keywords
The Chlamydia trachomatis p‐aminobenzoate synthase CADD is a manganese‐dependent oxygenase that uses its own amino acid residues as substrates
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14573
Abstract: CADD (chlamydia protein associating with death domains) is a p‐aminobenzoate (pAB) synthase involved in a noncanonical route for tetrahydrofolate biosynthesis in Chlamydia trachomatis. Although previously implicated to employ a diiron cofactor, here, we show that pAB… read more here.
Keywords: synthase; aminobenzoate synthase; chlamydia trachomatis; acid ... See more keywords
Development of an activity assay for characterizing deoxyhypusine synthase and its diverse reaction products
Sign Up to like & getrecommendations! Published in 2020 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13046
Abstract: Deoxyhypusine synthase transfers an aminobutyl moiety from spermidine to the eukaryotic translation initiation factor 5A (eIF5A) in the first step of eIF5A activation. This exclusive post‐translational modification is conserved in all eukaryotes. Activated eIF5A has… read more here.
Keywords: development activity; deoxyhypusine synthase; reaction; synthase ... See more keywords
Heterocyclic and Alkyne Terpenoids by Terpene Synthase‐Mediated Biotransformation of Non‐Natural Prenyl Diphosphates: Access to New Fragrances and Probes
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200211
Abstract: Two terpene cyclases were used as biocatalytic tool, namely, limonene synthase from Cannabis sativa (CLS) and 5‐epi‐aristolochene synthase (TEAS) from Nicotiana tabacum. They showed significant substrate flexibility towards non‐natural prenyl diphosphates to form novel terpenoids,… read more here.
Keywords: synthase; heterocyclic alkyne; natural prenyl; prenyl diphosphates ... See more keywords
How Can the Diterpene Synthase CotB2V80L Alter the Product Profile?
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DOI: 10.1002/cctc.202400711
Abstract: Structural diversity of diterpenes is mediated by the enigmatic family of diterpene synthases. The overall enzymatic contribution hereby lies in a carefully concerted chemistry of highly reactive carbocation intermediates mainly guided by aromatic and polar… read more here.
Keywords: synthase; chemistry; diterpene synthase; product profile ... See more keywords
Bioalkylation Strategies to Synthesize Allylated Tetrahydroisoquinolines by Using Norcoclaurine Synthase and O‐Methyltransferases
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DOI: 10.1002/cctc.202401668
Abstract: O‐Methyltransferase (O‐MT)‐mediated alkylations are of growing interest for the regioselective modification of bioactive motifs, although there are still few examples of applications with more structurally complex compounds. In this work, we have used O‐MTs for… read more here.
Keywords: synthase; norcoclaurine synthase; allylated tetrahydroisoquinolines; synthesize allylated ... See more keywords
Substrate specificity of α‐humulene synthase from Zingiber zerumbet Smith and determination of kinetic constants by a spectrophotometric assay
Sign Up to like & getrecommendations! Published in 2018 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.201800019
Abstract: Terpene synthases are the key enzymes in terpene biosynthesis that provide a structurally complex and highly diverse product spectrum. A suitable and reliable analytical assay is indispensable to measure terpene synthase activity accurately and precisely.… read more here.
Keywords: humulene synthase; zingiber zerumbet; zerumbet smith; synthase ... See more keywords
Structure, catalysis, and inhibition mechanism of prenyltransferase
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DOI: 10.1002/iub.2418
Abstract: Isoprenoids, also known as terpenes or terpenoids, represent a large family of natural products composed of five‐carbon isopentenyl diphosphate or its isomer dimethylallyl diphosphate as the building blocks. Isoprenoids are structurally and functionally diverse and… read more here.
Keywords: head; structure catalysis; synthase; prenyl synthase ... See more keywords
Perillaldehyde prevents the formations of atherosclerotic plaques through recoupling endothelial nitric oxide synthase
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DOI: 10.1002/jcb.27362
Abstract: Nitric oxide (NO) produced by endothelial NO synthase (eNOS) is essential for cardiovascular homeostasis owing to its anti‐inflammatory, antithrombotic, antiproliferative, and antioxidant effects. Perillaldehyde (PAH), one of the major oil components in Perilla frutescens, has… read more here.
Keywords: synthase; atherosclerotic plaques; perillaldehyde prevents; formations atherosclerotic ... See more keywords
Efficient Delivery of Globotriaosylceramide Synthase siRNA using Polyhistidine-Incorporated Lipid Nanoparticles.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200423
Abstract: In this study, a novel polyhistidine (pHis)-incorporated lipid nanoparticle (pHis/LNP) was developed for the delivery of therapeutic globotriaosylceramide (Gb3) synthase siRNAs using a microfluidic device with pHis as a biocompatible method of endosome escape. To… read more here.
Keywords: synthase; gb3 synthase; phis lnp; lnp ... See more keywords
Purification and Reconstitution of Ilyobacter tartaricus ATP Synthase.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8556-2_3
Abstract: F-type adenosine triphosphate (ATP) synthase is a membrane-bound macromolecular complex, which is responsible for the synthesis of ATP, the universal energy source in living cells. This enzyme uses the proton- or sodium-motive force to power… read more here.
Keywords: atp synthase; ilyobacter tartaricus; tartaricus atp; synthase ... See more keywords