Thymidylate synthase-catalyzed, tetrahydrofolate-dependent self-inactivation by 5-FdUMP.
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DOI: 10.1016/j.abb.2019.108106
Abstract: In view of previous crystallographic studies, N4-hydroxy-dCMP, a slow-binding thymidylate synthase inhibitor apparently caused "uncoupling" of the two thymidylate synthase-catalyzed reactions, including the N5,10-methylenetetrahydrofolate one-carbon group transfer and reduction, suggesting the enzyme's capacity to use… read more here.
Keywords: synthase; hydroxy dcmp; synthase catalyzed; thymidylate synthase ... See more keywords