Specific Aldosterone Synthase Inhibition: A Potential Improvement Over Mineralocorticoid Receptor Antagonism?
Sign Up to like & getrecommendations! Published in 2017 at "Hypertension"
DOI: 10.1161/hypertensionaha.116.07939
Abstract: See related article, pp 189–196 We have come to appreciate the many physiological and pathophysiological functions of adrenal steroid hormones in health and disease and the benefits and adverse effects of therapeutic manipulations. Glucocorticoids are… read more here.
Keywords: mineralocorticoid receptor; synthase inhibition; aldosterone synthase;
Aldosterone synthase inhibition: a novel bullet to fight cardiovascular-kidney metabolic syndrome.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-25-0047
Abstract: Aldosterone is synthesized by the CYP11B2 enzyme, primarily in the zona glomerulosa of the adrenal gland. It exerts its classical effects on sodium and water balance in the renal distal nephron through binding to the… read more here.
Keywords: synthase inhibition; aldosterone synthase; inhibition novel; aldosterone ... See more keywords