Mechanism of naphthoquinone selectivity of thymidylate synthase ThyX.
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DOI: 10.1016/j.bpj.2020.10.042
Abstract: Naphthoquinones (NQs) are natural and synthetic compounds with a wide range of biological activities commonly attributed to their redox activity and/or chemical reactivity. However, genetic and biochemical experiments have recently demonstrated that 2-hydroxy-NQs (2-OH-NQs) act… read more here.
Keywords: thymidylate synthase; thyx; mechanism; synthase thyx ... See more keywords