Syntheses and biological evaluation of BE-43547A2 analogues modified at O35 ester and C15-OH sites
Sign Up to like & getrecommendations! Published in 2019 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.12.053
Abstract: Abstract Total syntheses of 6 BE-43547A2 analogues modified at O35 and C15 sites are reported. Late stage oxidation of 15-deoxy-BE-43547A2 delivered 15-epi-BE-43547A2, which verified the proposition that the C15 is an active site for late… read more here.
Keywords: syntheses biological; c15; analogues modified; 43547a2 analogues ... See more keywords
Syntheses, Biological Evaluations, and Mechanistic Studies of Benzo[c][1,2,5]oxadiazole Derivatives as Potent PD-L1 Inhibitors with In Vivo Antitumor Activity.
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DOI: 10.1021/acs.jmedchem.1c00392
Abstract: A series of novel benzo[c][1,2,5]oxadiazole derivatives were designed, synthesized, and biologically evaluated as inhibitors of PD-L1. Among them, compound L7 exhibited 1.8 nM IC50 value in a homogeneous time-resolved fluorescence (HTRF) assay, which was 20-fold… read more here.
Keywords: oxadiazole derivatives; vivo antitumor; syntheses biological; value ... See more keywords
Syntheses and Biological Activities of triazole-based Sulfonamides
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DOI: 10.2174/1385272823666191021115023
Abstract: The triazole and sulfonamide compounds are known as biologically active agents that were employed for medicinal applications. These compounds were obtained in different forms by a variety of techniques to vast ranges of applications. The… read more here.
Keywords: biological activities; syntheses biological; chemistry; based sulfonamides ... See more keywords
Cannabinol: History, Syntheses, and Biological Profile of the Greatest “Minor” Cannabinoid
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DOI: 10.3390/plants11212896
Abstract: Cannabis (Cannabis sativa L.) is an outstanding source of bioactive natural products, with more than 150 different phytocannabinoids isolated throughout the decades; however, studies of their bioactivity have historically concentrated on the so-called “big four”… read more here.
Keywords: history syntheses; history; profile greatest; syntheses biological ... See more keywords