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Published in 2018 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.8b07161
Abstract: The antitumor tetrahydroisoquinoline (THIQ) alkaloids share a common pentacyclic scaffold that is biosynthesized by nonribosomal peptide synthetases involving unique enzymatic Pictet-Spengler cyclizations. Herein we report concise and divergent chemo-enzymatic total syntheses of THIQ alkaloids by…
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Keywords:
jorunnamycin saframycin;
total syntheses;
enzymatic total;
chemo enzymatic ... See more keywords