Enantioselective Syntheses of Tricyclic Benzimidazoles via Intramolecular Allylic Aminations with Chiral-Bridged Biphenyl Phosphoramidite Ligands.
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DOI: 10.1021/acs.orglett.8b03640
Abstract: The first iridium-catalyzed enantioselective intramolecular allylic aminations of benzimidazole-tethered allylic carbonates were developed, providing three classes of tricyclic benzimidazoles bearing a tertiary carbon stereogenic center in high yields and excellent enantioselectivities (up to 99% yield,… read more here.
Keywords: tricyclic benzimidazoles; allylic aminations; chiral bridged; enantioselective syntheses ... See more keywords