Soluble expression of mature Rhizopus chinensis lipase in Escherichia coli and enhancement of its ester synthesis activity.
Sign Up to like & getrecommendations! Published in 2019 at "Protein expression and purification"
DOI: 10.1016/j.pep.2019.06.003
Abstract: The production of membrane-associated lipase from Rhizopus chinensis (RCL), which has a high ester synthesis activity and important potential applications, is difficult in heterologous expression system such as Escherichia coli and often leads to the… read more here.
Keywords: ester synthesis; mrcl; expression; synthesis activity ... See more keywords
Design, Synthesis, and Activity Evaluation of C-23-Modified 5-O-Mycaminosyltylonolide Derivatives.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00458
Abstract: The widespread use of tylosin family drugs in clinical practice has led to bacterial resistance and reduced therapeutic efficacy. We designed and synthesized a series of new semisynthetic derivatives of tylosin with 5-O-mycaminosyltylonolide as the… read more here.
Keywords: antibacterial activity; activity evaluation; synthesis activity; design synthesis ... See more keywords
Synthesis and Activity of T-Cell Tumor-Directing MegaMolecules.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c07377
Abstract: This paper describes the synthesis, characterization, and functional activity of 26 MegaMolecule-based bispecific antibody mimics for T-cell redirection toward HER2+ cancer cells. The work reports functional bispecific MegaMolecules that bind both receptor targets, and recruit… read more here.
Keywords: activity cell; tumor; synthesis activity; antibody mimics ... See more keywords
Enhanced ammonia synthesis activity of Ru-supported cerium-lanthanum oxide induced by Ti substitution forming mesopores.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07014b
Abstract: Ru/Ce0.5La0.5-xTixO1.75+0.5x solid solutions with cubic fluorite structure were successfully synthesized via the polymerized complex method. While the Ti substitution enhanced Ce4+ reducibility by compensating for oxygen vacancies, the reducibility showed no correlation with ammonia synthesis… read more here.
Keywords: substitution; ammonia synthesis; enhanced ammonia; synthesis activity ... See more keywords
Regio-selective synthesis and activity research on 7-icaritin norcantharidin conjugates.
Sign Up to like & getrecommendations! Published in 2022 at "Natural product research"
DOI: 10.1080/14786419.2022.2121828
Abstract: Due to complexity of tumor diseases and resistance of targeted drug, targeted drug usually cannot meet the needs of cancer treatment. Therefore, the conjugate constructed by two anticancer agents maybe a better solution for the… read more here.
Keywords: selective synthesis; synthesis activity; icaritin; regio selective ... See more keywords
Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis‐surrogate keratinocytes and skin substitutes
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Dermatology"
DOI: 10.1111/ced.13024
Abstract: Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient… read more here.
Keywords: salicylic acid; acid ester; activity salicylic; ester bakuchiol ... See more keywords
Synthesis, Activity, Toxicity, and In Silico Studies of New Antimycobacterial N-Alkyl Nitrobenzamides
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceuticals"
DOI: 10.3390/ph17050608
Abstract: Tuberculosis (TB) is a disease that plagues the frailest members of society. We have developed a family of N-alkyl nitrobenzamides that exhibit promising antitubercular activities and can be considered a structural simplification of known inhibitors… read more here.
Keywords: activity toxicity; alkyl nitrobenzamides; known inhibitors; synthesis activity ... See more keywords