Selective Synthesis of N-Acylnortropane Derivatives in Palladium-Catalysed Aminocarbonylation
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DOI: 10.3390/molecules26061813
Abstract: The aminocarbonylation of various alkenyl and (hetero)aryl iodides was carried out using tropane-based amines of biological importance, such as 8-azabicyclo[3.2.1]octan-3-one (nortropinone) and 3α-hydroxy-8-azabicyclo[3.2.1]octane (nortropine) as N-nucleophile. Using iodoalkenes, the two nucleophiles were selectively converted to… read more here.
Keywords: derivatives palladium; selective synthesis; acylnortropane derivatives; synthesis acylnortropane ... See more keywords