Synthesis of an allosteric modulator of ionotropic glutamate receptors
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DOI: 10.1016/j.mencom.2020.03.008
Abstract: Synthesis of 6-[4-methoxy-3-(pyrrolidin-1-ylmethyl)benzyl]-1,11-dimethyl-3,6,9-triazatricyclo[7.3.1.13,11]tetradecane-4,8,12-trione has been carried out and optimized. In vitro studies using electrophysiological patch clamp technique have revealed a negative effect of this compound on kainateinduced currents in Purkinje neurons in a wide range… read more here.
Keywords: allosteric modulator; modulator ionotropic; glutamate receptors; ionotropic glutamate ... See more keywords