Asymmetric Cα-Alkylation of Proline via Chirality Transfers of Conformationally Restricted Proline Derivative: Application to the Total Synthesis of (-)-Amathaspiramide F.
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DOI: 10.1021/acs.orglett.8b02568
Abstract: An efficient strategy for the asymmetric synthesis of Cα-tetrasubstituted proline derivatives from proline has been established. A nitrogen-fused bicyclic system was devised to control the stereodynamics of proline. Through N-quaternizations with allylic electrophiles followed by… read more here.
Keywords: asymmetric alkylation; total synthesis; proline; alkylation proline ... See more keywords