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Published in 2019 at "Mendeleev Communications"
DOI: 10.1016/j.mencom.2019.11.028
Abstract: 1-(2-Aminoethylsulfonyl)-2-phosphorylpyrrolidines have been synthesized via boron trifluoride-catalyzed Arbuzov reaction of 2-ethoxy-1-(vinylsulfonyl)pyrrolidine with triethyl phosphite followed by aza-Michael reaction of thus obtained 2-phosphoryl-1-(vinylsulfonyl)pyrrolidine with secondary amines. The cytotoxicity of the prepared 1-(2-aminoethylsulfonyl)-2-phosphorylpyrrolidines against M-Hela tumor cell…
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Keywords:
consecutive arbuzov;
synthesis aminoethylsulfonyl;
via consecutive;
aza michael ... See more keywords