Synthesis of 2-aminopyridines via ruthenium-catalyzed [2+2+2] cycloaddition of 1,6- and 1,7-diynes with cyanamides: scope and limitations
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DOI: 10.1039/c7nj04933a
Abstract: A practical and mild process to access 2-aminopyridine derivatives using ruthenium-catalyzed [2+2+2] cycloaddition of various 1,6- and 1,7-diynes with cyanamides is described. This straightforward atom-economical catalytic cycloaddition is scalable and showed excellent regioselectivities to approach… read more here.
Keywords: cycloaddition; synthesis aminopyridines; catalyzed cycloaddition; ruthenium catalyzed ... See more keywords