Synthesis, anti‐inflammatory activity, and molecular docking studies of some novel Mannich bases of the 1,3,4‐oxadiazole‐2(3H)‐thione scaffold
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DOI: 10.1002/ardp.202000061
Abstract: A series of novel ibuprofen and salicylic acid‐based 3,5‐disubstituted‐1,3,4‐oxadiazole‐2(3H)‐thione derivatives was synthesized, and they were evaluated as potential anti‐inflammatory agents. Following the structure identification studies employing IR, 1H nuclear magnetic resonance (NMR), 13C NMR, and… read more here.
Keywords: anti inflammatory; docking studies; oxadiazole thione; synthesis anti ... See more keywords
Synthesis, anti‐TB activities, and molecular docking studies of 4‐(1,2,3‐triazoyl)arylmethanone derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22998
Abstract: Infectious diseases such as tuberculosis (TB) are leading causes of human death. Antibiotics are effective molecules to combat bacterial infections by affecting the processes required for bacterial cell growth and proliferation. The development of new… read more here.
Keywords: molecular docking; triazoyl arylmethanone; anti activities; arylmethanone derivatives ... See more keywords
Synthesis and anti-inflammatory activities of novel dihydropyranoaurone derivatives
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DOI: 10.1007/s12272-017-0910-5
Abstract: A novel series of dihydropyranoaurone derivatives were synthesized and evaluated as potential anti-inflammatory agents. Late-stage derivatization by versatile piperazine-catalyzed aldol reaction between dihydropyanobenzofuran intermediate 2 and diverse aldehydes readily afforded the novel dihydropyranoaurone analogs. Evaluation… read more here.
Keywords: anti inflammatory; dihydropyranoaurone derivatives; dihydropyranoaurone; novel dihydropyranoaurone ... See more keywords
Synthesis and anti-mitotic activity of 6,7-dihydro-4H-isothiazolo[4,5-b]pyridin-5-ones: In vivo and cell-based studies.
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DOI: 10.1016/j.ejmech.2016.09.075
Abstract: A series of 3,7-diaryl-6,7-dihydroisothiazolo [4,5-b]pyridin-5(4H)-ones 8 and 9 was synthesized by multicomponent condensation of 3-aryl-5-isothiazolecarboxylic acid esters 4a-f with aromatic (or thienyl) aldehydes 7 and Meldrum's acid in an acidic medium. The targeted compounds were… read more here.
Keywords: pyridin ones; cell based; synthesis anti; cell ... See more keywords
Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.037
Abstract: An efficient synthetic route for the synthesis of 2H-pyrazolo[4,3-c]pyridines, primarily varying by the substituents at the 2-, 4- and 6-positions, is described here. A Sonogashira-type cross-coupling reaction was employed to yield 3-alkynyl-1H-pyrazole-4-carbaldehydes, ethanones and propanones… read more here.
Keywords: anti mitotic; pyrazolo pyridines; synthesis anti; mitotic activity ... See more keywords
Synthesis of anti-tubercular marine alkaloids denigrins A and B
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DOI: 10.1016/j.tetlet.2018.06.013
Abstract: Abstract The first synthesis of anti-tubercular marine alkaloids denigrins A and B were accomplished in three and five steps and 62% and 31% overall yields respectively, from maleic anhydride. The key features of the synthesis… read more here.
Keywords: marine alkaloids; synthesis anti; anti tubercular; alkaloids denigrins ... See more keywords
Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids.
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DOI: 10.1021/acsmedchemlett.2c00078
Abstract: In the search of new antiplasmodial agents, a multitargeted approach was used in the synthesis of triazolopyrimidine- and 4-aminoquinolines-based hybrids. In vitro antiplasmodial evaluation on chloroquine-sensitive (3D7) and -resistant (W2) P. falciparum strains identified triazolopyrimidine-4-aminoquinoline… read more here.
Keywords: insights aminoquinoline; anti plasmodial; plasmodial activities; activities mechanistic ... See more keywords
Synthesis, anti-proliferative and apoptosis-inducing studies of palladacycles containing a diphosphine and a Sn,As-based chelate ligand.
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DOI: 10.1039/c8dt03875a
Abstract: Cleavage of the bromide bridges in [Pd2(μ-Br)2{κ2(Sn,As)-2-MeBrSnC6F4AsPh2}2] (1) by diphosphine ligands gave the mono- and dinuclear palladacycles [Pd(L)Br{κ2(Sn,As)-2-MeBrSnC6F4AsPh2}] [L = dppe (2) dppm (3), ortho-dppBz (4)] and [Pd2Br2(para-dppBz){κ2(Sn,As)-2-MeBrSnC6F4AsPh2}2] (5). The interactions of these complexes with… read more here.
Keywords: anti proliferative; apoptosis inducing; proliferative apoptosis; synthesis anti ... See more keywords
Synthesis, anti-mycobacterial and cytotoxic evaluation of substituted isoindoline-1,3-dione-4-aminoquinolines coupled via alkyl/amide linkers
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DOI: 10.1039/c8ra10532d
Abstract: A series of secondary amine-substituted isoindoline-1,3-dione-4-aminoquinolines were prepared via microwave heating and assayed for their anti-mycobacterial activities. read more here.
Keywords: anti mycobacterial; synthesis anti; isoindoline dione; dione aminoquinolines ... See more keywords
Synthesis and anti-osteoporosis activity of novel Teriparatide glycosylation derivatives
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DOI: 10.1039/d0ra05136e
Abstract: Osteoporosis is a metabolic bone disease that is characterized by low bone mass and micro-architectural deterioration of bones. The mechanism underlying this disease implicates an imbalance between bone resorption and bone remodeling. In 2002, the… read more here.
Keywords: anti osteoporosis; synthesis anti; glycosylation derivatives; teriparatide ... See more keywords
Microwave synthesis, anti-oxidant and anti-tumor activity of some nucleosides derived 2-oxonicotinonitrile
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DOI: 10.1080/00397911.2019.1672747
Abstract: Abstract A facile and convenient synthesis of novel cyclic and acyclic nucleoside derivatives incorporating 2-oxo-1,2-dihydropyridine-3-carbonitrile moiety has been described. The aglycons 3a,b were coupled with different activated halosugars such as glucosyl, galactosyl, lactosyl bromides and… read more here.
Keywords: anti oxidant; anti tumor; synthesis anti; microwave synthesis ... See more keywords