Asymmetric Total Synthesis of Antibiotic Elansolid A.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c01133
Abstract: Elansolid A is a structurally complex polyketide macrolactone natural product that exhibits promising antibacterial properties. Its challenging asymmetric total synthesis was achieved by a convergent strategy, in which the tetrahydroindane core of the molecule and… read more here.
Keywords: synthesis antibiotic; synthesis; antibiotic elansolid; asymmetric total ... See more keywords
A greatly improved procedure for the synthesis of an antibiotic-drug candidate 2,4-diacetylphloroglucinol over silica sulphuric acid catalyst: multivariate optimisation and environmental assessment protocol comparison by metrics
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DOI: 10.1039/d0ra05424k
Abstract: Efforts toward the development of a straightforward greener Gram-scale synthesis of the antibiotic compound 2,4-diacetylphloroglucinol (DAPG) have been developed. This beneficial procedure was accomplished through the Friedel–Crafts acylation of phloroglucinol over inexpensive heterogeneous silica sulphuric… read more here.
Keywords: silica sulphuric; sulphuric acid; environmental assessment; synthesis antibiotic ... See more keywords
Synthesis and Antibiotic Activity of Chitosan-Based Comb-like Co-Polypeptides
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DOI: 10.3390/md21040243
Abstract: Infections caused by multidrug-resistant Gram-negative bacteria have been named one of the most urgent global health threats due to antimicrobial resistance. Considerable efforts have been made to develop new antibiotic drugs and investigate the mechanism… read more here.
Keywords: chitosan based; synthesis antibiotic; antibiotic activity; activity chitosan ... See more keywords