Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1,3,4‐oxadiazole derivatives
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DOI: 10.1002/ardp.202200294
Abstract: Two new series of 1,3,4‐oxadiazoles bearing pyridine and thiazole heterocycles (4a‐h and 5a‐h) were synthesized (2,5‐disubstituted‐1,3,4‐oxadiazoles). The structures of these newly synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, high‐resolution mass… read more here.
Keywords: molecular docking; activity molecular; molecular dynamic; anticholinesterase activity ... See more keywords
Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives.
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DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with… read more here.
Keywords: amine; amine derivatives; synthesis anticholinesterase; anticholinesterase activity ... See more keywords
Synthesis and anticholinesterase activities of novel glycosyl benzoxazole derivatives
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DOI: 10.1177/1747519819901251
Abstract: Eight glycosyl benzoxazole derivatives are synthesized by nucleophilic addition reactions of glycosyl isothiocyanate with o-aminophenol in tetrahydrofuran. The reaction conditions are optimized, and good yields (86%–94%) were obtained. The structures of all new products are… read more here.
Keywords: anticholinesterase activities; synthesis anticholinesterase; novel glycosyl; benzoxazole derivatives ... See more keywords