Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-018-2258-x
Abstract: Twenty-eight compounds of the type N´-substituted-2-(5-nitroheterocyclic-2-yl)-3H-benzo[d]imidazole-5-carboxamide were obtained using as an oxidizing agent the nitrobenzene to obtain the benzimidazole scaffold, a modification of the Steglich esterification reaction was used to obtain the final compounds. The… read more here.
Keywords: synthesis antimalarial; apoptotic activities; antiproliferative apoptotic; antimalarial antiproliferative ... See more keywords
Total synthesis and antimalarial activity of mortiamides A-D.
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DOI: 10.1039/c9cc02864a
Abstract: Mortiamides A-D (1-4) are head-to-tail cyclic heptapeptides that were identified from a novel Mortierella sp. isolate obtained from marine sediments from Northern Canada. Herein we report the first total synthesis of mortiamides A-D (1-4) on… read more here.
Keywords: synthesis antimalarial; activity mortiamides; total synthesis; antimalarial activity ... See more keywords
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
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DOI: 10.3390/molecules25020299
Abstract: In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting… read more here.
Keywords: synthesis antimalarial; piperidine derivatives; antimalarial activity; disubstituted piperidine ... See more keywords
Synthesis and antimalarial activity of 7-chloroquinoline-tethered sulfonamides and their [1,2,3]-triazole hybrids.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0187
Abstract: Aim & background: Drugs with multiple bioactive moieties have the advantages of multiple modes of action and fewer chances of drug resistance. In continuation of our previous work of developing hybrid antimalarials, we present herein the synthesis… read more here.
Keywords: synthesis antimalarial; antimalarial activity; activity chloroquinoline; chloroquinoline tethered ... See more keywords