Synthesis, antimycobacterial, cytotoxicity, anti‐inflammatory, in silico studies and molecular dynamics of pyrazole‐embedded thiazolidin‐4‐one hybrids
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200444
Abstract: In the present investigation, we devolved and synthesized a new series of pyrazole‐embedded thiazolidin‐4‐one derivatives (9a–p) with the goal to produce promising antitubercular leads. The in vitro antimycobacterial activity of the synthesized compounds was tested… read more here.
Keywords: thiazolidin one; pyrazole embedded; anti inflammatory; embedded thiazolidin ... See more keywords
Synthesis and antimycobacterial activity of pyridinium compounds with sulfonylacetamide substituent in N-alkyl chain
Sign Up to like & getrecommendations! Published in 2018 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/s10593-018-2362-3
Abstract: Pyridines containing amine, amide, or hydrazide substituent were quaternized with (ω-haloalkyl)sulfonylacetamides, resulting in new pyridinium compounds that exhibited tuberculostatic activity against the strain H37Rv of Mycobacterium tuberculosis. read more here.
Keywords: pyridinium compounds; antimycobacterial activity; substituent; synthesis antimycobacterial ... See more keywords
Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives
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DOI: 10.1016/j.cclet.2018.08.005
Abstract: Abstract We report herein the design and synthesis of a series of novel nitrobenzamide derivatives. Results reveal that many of them display considerable in vitro antitubercular activity. Four N-benzyl or N-(pyridine-2-yl)methyl 3,5-dinitrobenzamides A6, A11, C1… read more here.
Keywords: synthesis antimycobacterial; design synthesis; nitrobenzamide derivatives; antimycobacterial activity ... See more keywords
Synthesis and antimycobacterial activity of triterpeni≿ A-ring azepanes.
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DOI: 10.1016/j.ejmech.2017.11.035
Abstract: A series of A-ring azepanones and azepanes derived from betulonic, oleanonic and ursonic acids was synthesized and evaluated for their in vitro antimycobacterial activities against M. tuberculosis (MTB) H37Rv and SDR-TB in the National Institute of Allergy… read more here.
Keywords: antimycobacterial activity; mtb h37rv; activity triterpeni; triterpeni ring ... See more keywords
Synthesis and antimycobacterial activity of 1-(β-d-Ribofuranosyl)-4-coumarinyloxymethyl- / -coumarinyl-1,2,3-triazole.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.02.067
Abstract: A series of β-d-ribofuranosyl coumarinyl-1,2,3-triazoles have been synthesized by Cu-catalyzed cycloaddition reaction between azidosugar and 7-O-/7-alkynylated coumarins in 62-70% overall yields. The in vitro antimycobacterial activity evaluation of the synthesized triazolo-conjugates against Mycobacterium tuberculosis revealed that… read more here.
Keywords: antimycobacterial activity; ribofuranosyl; inha dna; dna gyrase ... See more keywords
Synthesis and Antimycobacterial Activity of 2,5-Disubstituted and 1,2,5-Trisubstituted Benzimidazoles
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DOI: 10.3389/fchem.2020.00433
Abstract: The appearance of drug-resistant strains of Mycobacterium tuberculosis and the dramatic increase in infection rates worldwide evidences the urgency of developing new and effective compounds for treating tuberculosis. Benzimidazoles represent one possible source of new… read more here.
Keywords: antimycobacterial activity; trisubstituted benzimidazoles; activity disubstituted; tuberculosis ... See more keywords
Synthesis and Antimycobacterial Evaluation of N-(4-(Benzyloxy)benzyl)-4-aminoquinolines
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27082556
Abstract: Tuberculosis remains a global health problem that affects millions of people around the world. Despite recent efforts in drug development, new alternatives are required. Herein, a series of 27 N-(4-(benzyloxy)benzyl)-4-aminoquinolines were synthesized and evaluated for… read more here.
Keywords: benzyloxy benzyl; synthesis antimycobacterial; evaluation benzyloxy; antimycobacterial evaluation ... See more keywords