QSAR‐driven synthesis of antiproliferative chalcones against SH‐SY5Y cancer cells: Design, biological evaluation, and redesign
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200042
Abstract: Neuroblastoma is one of the most frequent types of cancer found in infants, and traditional chemotherapy has limited efficacy against this pathology. Thus, the development of new compounds with higher activity and selectivity than traditional… read more here.
Keywords: driven synthesis; activity; synthesis antiproliferative; cancer ... See more keywords
Synthesis and Antiproliferative Evaluation of New Pyrimido[1,6-a]Thieno[2,3-d]Pyrimidine Derivatives
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DOI: 10.1002/jhet.2592
Abstract: A facile one-pot synthesis of new pyrimido[1,6-a]thieno[2,3-d]pyrimidin-4-ones , is reported via base-catalyzed reaction of 2-amino-3-cyanothiophenes , with 2,4-dichloro-5-bromo-6-methylpyrimidine . Subsequent treatment of the products with several amines under a mild condition gave a host of… read more here.
Keywords: new pyrimido; cell; pyrimido thieno; synthesis antiproliferative ... See more keywords
Synthesis and antiproliferative activity of new hybrids bearing neocryptolepine, acridine and α-aminophosphonate scaffolds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01849-2
Abstract: Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3 , aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol. The… read more here.
Keywords: activity new; synthesis antiproliferative; antiproliferative activity; cancer cell ... See more keywords
Synthesis, antiproliferative activity and molecular docking of thiocolchicine urethanes.
Sign Up to like & getrecommendations! Published in 2018 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.09.004
Abstract: A number of naturally occurring compounds such as paclitaxel, vinblastine, combretastatin, and colchicine exert their therapeutic effect by changing the dynamics of tubulin and its polymer form, microtubules. The identification of tubulin as a potential… read more here.
Keywords: thiocolchicine; molecular docking; antiproliferative activity; synthesis antiproliferative ... See more keywords
Synthesis and antiproliferative activity of monocationic arylthiophene derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2016.12.007
Abstract: Eleven compounds of substituted 4-(5-arylthiophen-2-yl)benzamidines 4a-k were synthesized from their corresponding mononitriles via treatment with lithium trimethylsilylamide and subsequent de-protection with ethanol/hydrogen chloride. In vitro antiproliferative activities of the new monocationic arylthiophenes were evaluated against 60… read more here.
Keywords: tested monocations; cell lines; activity monocationic; synthesis antiproliferative ... See more keywords
Synthesis and antiproliferative activity of podocarpane and totarane derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.09.051
Abstract: The synthesis of podocarpanes, including 12,19-dihydroxy-13-acetyl-8,11,13-podocarpatriene (23), isolated from Gaultheria yunnanensis and not previously synthesized, and totarane-type terpenoids, starting from the natural labdane trans-communic acid (15), is described. Their antiproliferative activities against MCF-7, T-84 and… read more here.
Keywords: podocarpane totarane; activity podocarpane; synthesis antiproliferative; antiproliferative activity ... See more keywords
Total Synthesis of Antiproliferative Parvifloron F.
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DOI: 10.1021/acs.orglett.7b03763
Abstract: The first total synthesis of parvifloron F, a bioactive highly oxidized abietane diterpene, was achieved. The abietane skeleton was constructed by Lewis acid promoted cyclization. Preliminary structure-activity relationship correlations were established for the synthetic intermediates… read more here.
Keywords: total synthesis; antiproliferative parvifloron; synthesis antiproliferative; synthesis ... See more keywords
Design, synthesis, and antiproliferative activities of stapled melittin peptides
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra26427a
Abstract: Melittin is a 26-residue, amphipathic, cell-penetrating, α-helical anti-hepatoma peptide isolated from bee venom. However, the application of melittin as a drug is limited owing to its original conformational flexibility and low stability. In this study,… read more here.
Keywords: design synthesis; melittin; activities stapled; synthesis antiproliferative ... See more keywords
Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives
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DOI: 10.1055/s-0037-1610146
Abstract: Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell… read more here.
Keywords: properties bifunctional; bifunctional allocolchicine; antiproliferative properties; synthesis antiproliferative ... See more keywords
Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives
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DOI: 10.1080/07391102.2020.1848627
Abstract: Abstract A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8,… read more here.
Keywords: activity evaluation; synthesis antiproliferative; design synthesis; activity ... See more keywords
Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents.
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DOI: 10.1080/14786419.2022.2056889
Abstract: Piscidinol A (1), a major compound isolated from Aphanamixis polystachya, showed modest anticancer activity against cancer cell lines. Subsequently, a series of analogues were synthesised by modification of the key structural functionalities of this high… read more here.
Keywords: potential anticancer; cell; antiproliferative activities; synthesis antiproliferative ... See more keywords