Synthesis and Antitumor Evaluation of Novel Hybrids of Phenylsulfonylfuroxan and Estradiol Derivatives
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DOI: 10.1002/open.201900228
Abstract: Abstract Fifteen novel furoxan‐based nitric oxide (NO) releasing hybrids of estradiol derivatives were synthesized and evaluated in vitro anti‐proliferative activity in MDA‐MB‐231, A2780, Hela and HUVEC cell lines. Most of them displayed potent anti‐proliferative effects. Among… read more here.
Keywords: antitumor evaluation; novel hybrids; estradiol derivatives; evaluation novel ... See more keywords
Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors.
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DOI: 10.1016/j.bioorg.2020.103737
Abstract: PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogues and four thiazole analogues were designed and synthesized. Their enzymaticactivity… read more here.
Keywords: design synthesis; synthesis antitumor; activity theoretical; antitumor activity ... See more keywords
Photoinduced synthesis and antitumor activity of a phakellistatin 18 analog with an isoindolinone fragment
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DOI: 10.1039/d0nj03005h
Abstract: Photoinduced synthesis and antitumor activity of a phakellistatin 18 analog with an isoindolinone fragment. read more here.
Keywords: synthesis antitumor; analog isoindolinone; antitumor activity; phakellistatin analog ... See more keywords
Design, synthesis and antitumor activity of 5-trifluoromethylpyrimidine derivatives as EGFR inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2128797
Abstract: Abstract A new series of 5-trifluoromethylpyrimidine derivatives were designed and synthesised as EGFR inhibitors. Three tumour cells A549, MCF-7, PC-3 and EGFR kinase were employed to evaluate their biological activities. The results were shown that… read more here.
Keywords: design synthesis; antitumor activity; egfr inhibitors; synthesis antitumor ... See more keywords
Synthesis, antitumor activity, molecular docking and DFT study of Novel pyrimidiopyrazole derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Current computer-aided drug design"
DOI: 10.2174/1573409915666190710094425
Abstract: In this investigation, the reaction of 2-cyano-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl) acetamide (3) with dimethylformamide dimethyl acetal (DMF-DMA) to afford the corresponding (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamide (4) utilizing microwave irradiation. The condensation reactions of (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydro pyrimidin-5-yl) acrylamide (4) with hydrazine derivatives to… read more here.
Keywords: synthesis antitumor; activity molecular; molecular docking; antitumor activity ... See more keywords
Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives
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DOI: 10.3390/ijms24108686
Abstract: A series of indazole derivatives were designed and synthesized by molecular hybridization strategy, and these compounds were evaluated the inhibitory activities against human cancer cell lines of lung (A549), chronic myeloid leukemia (K562), prostate (PC-3),… read more here.
Keywords: activity indazole; design synthesis; cell; compound ... See more keywords