Synthesis and Antiviral Evaluation of 3′‐Fluoro‐4′‐modified‐5′‐norcarbocyclic Nucleoside Phosphonates
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DOI: 10.1002/cmdc.201800804
Abstract: The synthesis and anti‐HIV evaluation of hitherto unknown 3′‐fluoro‐5′‐norcarbocyclic nucleoside phosphonates bearing adenine with modifications at the 4′ position (ethynyl, vinyl, ethyl, hydroxymethyl) is described. One of the synthesized compounds was found to be an… read more here.
Keywords: norcarbocyclic nucleoside; nucleoside phosphonates; antiviral evaluation; evaluation fluoro ... See more keywords
Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin
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DOI: 10.1002/cmdc.202000260
Abstract: The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Herein, we describe… read more here.
Keywords: derivatives teicoplanin; perfluoroalkyl derivatives; antiviral perfluoroalkyl; teicoplanin vancomycin ... See more keywords
SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL 3-SUBSTITUTED PYRAZOLINIUM SALTS
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DOI: 10.1007/6071
Abstract: For the first time, convenient methods for the preparation of pyrazoline N-alkylidene salts based on terpene (camphor, camphorquinone, carvone) ketones, cage (adamantanone and norcamphor) ketones, and natural aldehydes (carvone and myrtenal) allowing the isolation of… read more here.
Keywords: activity novel; antiviral activity; pyrazolinium salts; activity ... See more keywords
Synthesis and antiviral activity of 1-hydroxy-2-(2-hydroxyphenyl)imidazoles against vaccinia virus
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DOI: 10.1007/s11172-019-2467-6
Abstract: Abstract2-(2-Hydroxyplienyl)imidazole derivatives were synthesized and tested for antiviral activity against vaccinia virus in Vero cell culture. 1-Methylimidazole 3-oxides, 1-methoxyimidazoles, and 1H-imidazoles showed no activity, whereas some 1-hydroxyimidazole derivatives hold promise, exhibiting antiviral activity and weak… read more here.
Keywords: activity hydroxy; antiviral activity; vaccinia virus; hydroxy hydroxyphenyl ... See more keywords
Synthesis, antiviral, DFT and molecular docking studies of some novel 1,2,4-triazine nucleosides as potential bioactive compounds.
Sign Up to like & getrecommendations! Published in 2021 at "Carbohydrate research"
DOI: 10.1016/j.carres.2021.108246
Abstract: A novel series of nucleosides with potential antiviral activity have been synthesized and characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the synthesized compounds was assessed against the Coxsackie… read more here.
Keywords: nucleosides potential; synthesis antiviral; dft molecular; docking studies ... See more keywords
Highly convergent synthesis and antiviral activity of (E)-but-2-enyl nucleoside phosphonoamidates
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Medicinal Chemistry"
DOI: 10.1016/j.ejmech.2018.01.086
Abstract: Abstract Several hitherto unknown (E)-but-2-enyl nucleoside phosphonoamidate analogs (ANPs) were prepared directed with nitrogen reagents by cross-metathesis in water-under ultrasound irradiation. Two diastereoisomers were formally identified by X-ray diffraction. These compounds were evaluated against a… read more here.
Keywords: enyl; antiviral activity; enyl nucleoside; highly convergent ... See more keywords
Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.7b00179
Abstract: In our attempt to optimize the lead HIV-1 entry antagonist, NBD-11021, we present in this study the rational design and synthesis of 60 new analogues and determination of their antiviral activity in a single-cycle and… read more here.
Keywords: potency; vitro admet; structure; ray structure ... See more keywords
Asymmetric Synthesis of the Antiviral Diterpene Wickerol A.
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DOI: 10.1021/jacs.7b05046
Abstract: Wickerol A (1) is an unusual diterpene with remarkable activity against the H1N1 influenza virus. Its tetracyclic skeleton contains three quaternary carbons and is marked by several syn-pentane interactions which force a six-membered ring into… read more here.
Keywords: synthesis antiviral; wickerol; asymmetric synthesis; synthesis ... See more keywords
Multicomponent reactions in the synthesis of antiviral compounds.
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DOI: 10.2174/0929867328666211007121837
Abstract: BACKGROUND Multicomponent reactions are one-pot processes for the synthesis of highly functionalized hetero-cyclic and hetero-acyclic compounds, often endowed with biological activity. OBJECTIVE Multicomponent reactions are considered green processes with high atom economy. In addition, they… read more here.
Keywords: multicomponent reactions; reactions synthesis; chemistry; antiviral compounds ... See more keywords
Synthesis and Antiviral Evaluation of 3′-Fluoro-5′-norcarbocyclic Nucleoside Phosphonates Bearing Uracil and Cytosine as Potential Antiviral Agents
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DOI: 10.3390/molecules25163708
Abstract: Carbocyclic nucleoside analogues are an essential class of antiviral agents and are commonly used in the treatment of viral diseases (hepatitis B, AIDS). Recently, we reported the racemic synthesis and the anti-human immunodeficiency virus activities… read more here.
Keywords: synthesis antiviral; norcarbocyclic nucleoside; nucleoside phosphonates; antiviral agents ... See more keywords
5′-Nor-3-Deaza-1′,6′-Isoneplanocin, the Synthesis and Antiviral Study
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DOI: 10.3390/molecules25173865
Abstract: The arbocyclic nucleosides aristeromycin and neplanocin have been studied as a source for new antiviral agents. A convenient synthesis of C-5′-truncated 3-deaza-1′,6′-isoneplanocin, which combines the features of antiviral candidates 5′-noraristeromycin and 3-deaza-1′,6′-isoneplanocin is reported from… read more here.
Keywords: deaza isoneplanocin; antiviral study; isoneplanocin synthesis; synthesis ... See more keywords