Atroposelective Synthesis of N-Arylindoles via Enantioselective N-H Bond Insertion.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03003
Abstract: We present here a rhodium-catalyzed asymmetric N-H insertion reaction, which is a concerted process revealed by DFT calculations, for the synthesis of novel axially chiral N-arylindoles by the reaction between indoles and diazonaphthoquinones. The reaction… read more here.
Keywords: synthesis arylindoles; synthesis; insertion; arylindoles via ... See more keywords
Straightforward synthesis of N-arylindoles via one-pot Fischer indolisation–indole N-arylation
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d3ra02658b
Abstract: A microwave-promoted, one-pot, three-component synthesis of N-arylindoles has been developed, utilising sequential Fischer indolisation then copper(i)-catalysed indole N-arylation. Novel arylation conditions were identified that use a simple and cheap catalyst/base system (Cu2O/K3PO4) in an environmentally… read more here.
Keywords: synthesis arylindoles; fischer indolisation; one pot;