Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists
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DOI: 10.1002/cmdc.202100029
Abstract: The synthesis of 5‐formyl‐6‐aryl‐6H‐indolo[3,2,1‐de][1,5] naphthyridine‐2‐carboxylates by reaction between 1‐formyl‐9H‐β‐carbolines and cinnamaldehydes in the presence of pyrrolidine in water with microwave irradiation is described. Pharmacophoric modification of the formyl group offered several new fused β‐carboline derivatives,… read more here.
Keywords: opioid receptor; synthesis assessment; carboline derivatives; assessment fused ... See more keywords
Synthesis and Assessment of Novel Probes for Imaging Tau Pathology in Transgenic Mouse and Rat Models
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DOI: 10.1021/acschemneuro.0c00790
Abstract: Aggregated tau protein is a core pathology present in several neurodegenerative diseases. Therefore, the development and application of positron emission tomography (PET) imaging radiotracers that selectively bind to aggregated tau in fibril form is of… read more here.
Keywords: tau; brain sections; synthesis assessment; pathology ... See more keywords
Electrospinning synthesis and assessment of physicochemical properties and biocompatibility of cobalt nitrate fibers for wound healing applications.
Sign Up to like & getrecommendations! Published in 2019 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765201920180237
Abstract: The aim of this study was to develop polyurethane (PU) wound dressing incorporated with cobalt nitrate using electrospinning technique. The morphology analysis revealed that the developed composites exhibited reduced fiber and pore diameter than the… read more here.
Keywords: electrospinning synthesis; cobalt; synthesis assessment; assessment physicochemical ... See more keywords