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   Articles with "synthesis azabicyclo" as a keyword



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The synthesis of 3-azabicyclo[4.3.0]nonane scaffolds from brefeldin A

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recommendations! Published in 2020 at "Tetrahedron Letters"

DOI: 10.1016/j.tetlet.2020.152006

Abstract: Abstract Brefeldin A (BFA) is a fungal metabolite that displays a wide range of biological activities making it an attractive target for drug discovery. To explore the biological potential of the BFA scaffold an amine-macrocycle… read more here.

Keywords: bfa; azabicyclo nonane; scaffolds brefeldin; synthesis ... See more keywords

Synthesis of Azabicyclo[3.1.1]heptenes Enabled by Catalyst-Controlled Annulations of Bicyclo[1.1.0]butanes with Vinyl Azides.

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c04485

Abstract: Bridged bicyclic scaffolds are emerging bioisosteres of planar aromatic rings under the concept of "escape from flatland". However, adopting this concept into the exploration of bioisosteres of pyridines remains elusive due to the challenge of… read more here.

Keywords: synthesis azabicyclo; vinyl azides; azabicyclo heptenes; bioisosteres pyridines ... See more keywords

Divergent Synthesis of 1‑Azabicyclo[n.1.1]alkane Bioisosteres via Photoinduced Palladium Catalysis

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recommendations! Published in 2025 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.5c09500

Abstract: Nitrogen heterocycles are indispensable structural motifs in pharmaceuticals, agrochemicals, and materials science. However, the development of new synthetic methods to access these frameworks remains a significant challenge. Here, we describe a switchable radical approach for… read more here.

Keywords: synthesis azabicyclo; azabicyclo alkane; divergent synthesis; synthesis ... See more keywords

Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks

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recommendations! Published in 2018 at "Synthesis"

DOI: 10.1055/s-0037-1609434

Abstract: An approach to 2-azabicyclo[n.2.0]alkane derivatives (n = 1, 2), which relies on a tandem Strecker reaction–intramolecular nucleophilic cyclization (STRINC) sequence of the corresponding 2-(ω-chloroalkyl)cyclobutanones (in turn prepared by [2+2] cycloaddition of keteniminium salts and ethylene) is… read more here.

Keywords: azabicyclo alkane; alkane; synthesis azabicyclo; alkane derived ... See more keywords