The synthesis of 3-azabicyclo[4.3.0]nonane scaffolds from brefeldin A
Sign Up to like & getrecommendations! Published in 2020 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2020.152006
Abstract: Abstract Brefeldin A (BFA) is a fungal metabolite that displays a wide range of biological activities making it an attractive target for drug discovery. To explore the biological potential of the BFA scaffold an amine-macrocycle… read more here.
Keywords: bfa; azabicyclo nonane; scaffolds brefeldin; synthesis ... See more keywords
Synthesis of 2-Azabicyclo[n.2.0]alkane-Derived Building Blocks
Sign Up to like & getrecommendations! Published in 2018 at "Synthesis"
DOI: 10.1055/s-0037-1609434
Abstract: An approach to 2-azabicyclo[n.2.0]alkane derivatives (n = 1, 2), which relies on a tandem Strecker reaction–intramolecular nucleophilic cyclization (STRINC) sequence of the corresponding 2-(ω-chloroalkyl)cyclobutanones (in turn prepared by [2+2] cycloaddition of keteniminium salts and ethylene) is… read more here.
Keywords: azabicyclo alkane; alkane; synthesis azabicyclo; alkane derived ... See more keywords