Synthesis of 5-azido-3-nitro-1H-1,2,4-triazole by using a cyanoethyl activating group
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DOI: 10.1007/s10593-017-2115-8
Abstract: A new method is proposed for the preparation of 5-azido-3-nitro-1H-1,2,4-triazole, based on cyanoethylation of 5-bromo-3-nitro-1H-1,2,4-triazole, nucleophilic substitution of bromide with azide ion, and removal of cyanoethyl protecting group. read more here.
Keywords: azido nitro; synthesis azido; group; nitro triazole ... See more keywords
A re-investigation of the Fries rearrangement of 3-chlorophenyl acetate and synthesis of 2-azido-1-(4-(benzyloxy)-2-chlorophenyl)ethanone from 4-bromo-3-chlorophenol
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DOI: 10.1016/j.tetlet.2017.11.016
Abstract: Abstract The Fries rearrangement of 3-chlorophenyl acetate provided the expected 4-chloro-2-hydroxy-acetophenone as the major product and 2,4-diacetyl resorcinol and 2-chloro-4-hydroxy-acetophenone as minor products. 4-Benzyloxy-2-chloroacetophenone was prepared by a Heck reaction and then elaborated to 4-benzyloxy-2-chlorophenacyl… read more here.
Keywords: synthesis azido; fries rearrangement; investigation fries; acetate synthesis ... See more keywords
Synthesis of azido-substituted benzaldehydes via S Ar chemistry
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DOI: 10.1016/j.tetlet.2020.151899
Abstract: Abstract Conditions for the formation of azidobenzaldehydes and azidobenzonitriles using sodium azide in DMSO under typical SNAr conditions are described. This simplifies access to these valuable building blocks compared to the more common sequences reported… read more here.
Keywords: synthesis azido; chemistry; substituted benzaldehydes; benzaldehydes via ... See more keywords
Synthesis of Azido-Globo H Analogs for Immunogenicity Evaluation
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DOI: 10.1021/acscentsci.1c01277
Abstract: Globo H (GH) is a tumor-associated carbohydrate antigen (TACA), and GH conjugations have been evaluated as potential cancer vaccines. However, like all carbohydrate-based vaccines, low immunogenicity is a major issue. Modifications of the TACA increase… read more here.
Keywords: immunogenicity; synthesis azido; evaluation; azido analogs ... See more keywords
Synthesis of (2S,3R,5R)-2-Azido-3,5-dihydroxynonadecane Sphingolipid Analogue
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DOI: 10.1055/s-0040-1707397
Abstract: A concise and highly efficient synthesis of an enigmol analogue has been achieved. The synthetic strategy features Jacobsen’s hydrolytic kinetic resolution (HKR) and epoxide opening by alkynyl boranes as the key steps. read more here.
Keywords: synthesis azido; dihydroxynonadecane sphingolipid; azido dihydroxynonadecane; sphingolipid analogue ... See more keywords