Synthesis of Bempedoic Acid through Electrochemical Decarboxylation of Dialkylated Malonic Acid
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DOI: 10.1055/a-1482-9822
Abstract: Bempedoic acid is a small-molecule inhibitor of adenosine triphosphate-citrate lyase (ACL) that is effective in the treatment of hypercholesterolemia and hypertension. In this paper, a new, six-step synthesis of bempedoic acid with 42% overall yield… read more here.
Keywords: bempedoic; synthesis bempedoic; decarboxylation dialkylated; electrochemical decarboxylation ... See more keywords